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Cognitive outcome at 5years in very premature children without severe early cerebral abnormalities. Relationships with EEG at 6weeks after birth

Abstract : Aims of the study This prospective study aimed to analyze the relationship between EEG at 6 weeks after birth and cognitive outcome at the age of 5 in children born very preterm who did not present with severe neonatal cerebral abnormalities. Patients and methods EEGs were recorded at 6 weeks of age in infants born < 29 weeks of gestation or weighing < 1000 g at birth. At 5 years, study participants underwent a neurological assessment and cognitive evaluation with the Kaufman Assessment Battery for Children (K-ABC). Results Fifty-eight children had an EEG at 6 weeks after birth. Fifty-one were evaluated at 5 years. Twenty-six children (51.0%) had one or more disabilities: neuromotor, sensory, behavioral, and/or cognitive. Children with EEG abnormalities had significantly more disabilities (20 of 25, 80%) than children with normal EEG (6 of 26, 23%) (P = 0.0002). Thirty-five children underwent complete K-ABC assessment. Multiple linear regression analysis indicated a significant relationship between the overall EEG abnormalities (normal, dysmature, and/or disorganized) and two scales: mental processing composite (MPC) scales (P = 0.0121), and sequential processing scales (P = 0.0012). Dysmature EEGs were more predictive of lower MPC and sequential processing scales than disorganized EEGs. Immature occipital slow waves (i.e., too high for conceptional age) were consistently recorded in children with dysmature EEGs and associated with the lowest K-ABC scores. Conclusion EEG abnormalities recorded at 6 weeks after birth, such as immature occipital slow waves, were associated with later cognitive impairments. EEG at 6 weeks can be an early and reliable tool for assessing the risk of future cognitive impairment.
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https://hal.univ-lorraine.fr/hal-01709023
Contributor : Devah Ul <>
Submitted on : Wednesday, February 14, 2018 - 2:13:02 PM
Last modification on : Tuesday, October 13, 2020 - 10:46:32 AM

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D. Selton, M. Andre, C. Debruille, H. Deforge, J.-M. Hascoët. Cognitive outcome at 5years in very premature children without severe early cerebral abnormalities. Relationships with EEG at 6weeks after birth. Neurophysiologie Clinique/Clinical Neurophysiology, Elsevier Masson, 2013, 43 (5-6), pp.289 - 297. ⟨10.1016/j.neucli.2013.09.003⟩. ⟨hal-01709023⟩

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