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UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

Abstract : Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.
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https://hal.univ-lorraine.fr/hal-01715261
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Cristina Militti, Sylvain Maenner, Peter Becker, Fátima Gebauer. UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. Nature Communications, Nature Publishing Group, 2014, 5, ⟨10.1038/ncomms5762⟩. ⟨hal-01715261⟩

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