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Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?

Abstract : Thanks to their immune properties, the mesenchymal stem cells (MSC) are a promising source for cell therapy. Current clinical trials show that MSC administrated to patients can treat different diseases (graft-versus-host disease (GVHD), liver cirrhosis, systemic lupus, erythematosus, rheumatoid arthritis, type I diabetes…). In this case, the most common mode of cell administration is the intravenous injection, and the hemodynamic environment of cells induced by blood circulation could interfere on their behavior during the migration and homing towards the injured site. After a brief review of the mechanobiology concept, this paper will help in understanding how the mechanical environment could interact with MSC behavior once they are injected to patient in cell-based treatment.
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Contributor : Céline Huselstein Connect in order to contact the contributor
Submitted on : Thursday, February 22, 2018 - 4:04:10 PM
Last modification on : Wednesday, November 3, 2021 - 7:55:49 AM



Céline Huselstein, R. Rahouadj, Natalia de Isla, Danièle Bensoussan, Jean-François Stoltz, et al.. Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?. 6th International Symposium Europe China Molecular, cellular and tissue engineering, and clinical applications - First meeting of the CNRS GDRI France-China n°0851 “Mesenchymal Stem Cells and Regenerative Medicine, Jul 2016, Nancy, France. pp.S47 - S56, ⟨10.3233/BME-171623⟩. ⟨hal-01715376⟩



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