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Is isoproterenol really required during electrophysiological study in patients with Wolff-Parkinson-White syndrome?

Abstract : We have studied the results of electrophysiological study (EPS) in patients with Wolff-Parkinson-White syndrome (WPW) and spontaneous adverse clinical presentation and determined whether isoproterenol added incremental value. METHODS: EPS was performed in 63 patients with WPW and adverse clinical presentation at baseline. EPS was repeated after infusion of isoproterenol in 37 patients, including 25 without criteria for a malignant form at baseline. RESULTS: Atrioventricular orthodromic tachycardia was induced 44%, antidromic tachycardia in 11%, atrial fibrillation (AF) in 68% at baseline. At baseline EPS, criteria for a malignant form (AF induction and shortest CL <250 ms) were noted in 60%; tachycardia was not inducible in 16%. All the patients met the criteria for a malignant form after isoproterenol. CONCLUSIONS: EPS at baseline missed 16% of patients at risk of life-threatening arrhythmias who had no inducible tachyarrhythmia and 40% without classical criteria for malignant form.
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https://hal.univ-lorraine.fr/hal-01718098
Contributor : Iadi Ul <>
Submitted on : Tuesday, February 27, 2018 - 10:15:54 AM
Last modification on : Thursday, May 27, 2021 - 5:11:31 PM

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Maheshwar Pauriah, Gabriel Cismaru, Jean-Marc Sellal, Christian De Chillou, Béatrice Brembilla-Perrot. Is isoproterenol really required during electrophysiological study in patients with Wolff-Parkinson-White syndrome?. Journal of Electrocardiology, Elsevier, 2013, 46 (6), pp.686 - 692. ⟨10.1016/j.jelectrocard.2012.12.019⟩. ⟨hal-01718098⟩

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