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Master thesis

Optimisation des techniques de radiothérapie dans le cadre de la prise en charge des patientes traitées par radiochimiothérapie d'un cancer du col de l'utérus

Abstract : The aim of our study was to compare our results in term of survival, acute and late toxicity to those of the literature, and to determine if increase in the volume irradiated in brachytherapy (V60) and in extemal radiotherapy were predictive complications, in the patients of stage >= IB2 treated by radiochemotherapy.Materials and Methods : 97 patients of average age 49,4 years reached of cancers of the cervix cancer of stage >= IB2 (17 IB2, 12 lIA, 21 IlB, 1 IlIA, 34 I1IB, 4 IV A and 8 IVB), were included in our retrospective study. All the patients received a chemotherapy containing platinum salt (CDDP-5FU or Carbo-5FU or CDDP weekly) in a concomitant way to the radiotherapy, 94 patients had brachytherapy and 55 patients profited from a surgery. Results : The average follow-up of the patients was 34,2 months. The patients whose V60 was higher than 70 Cm3, had more late toxicities (rank 2,3,4) 61,7% that the patients whose V60 was lower than 70 Cm3, 33,3% (p=0,02). Size of the fields of extemal radiotherapy, as weil as the protocol of chemotherapy did not modify the rate of late complications nor acute. The surgery increased late toxicities (rank 3, 4), II,3% in the event of surgery vs 0% in the absence of surgery (p=0,02). Survival at 2 years is 86%. Survival without event is 83% to 2 years. Conclusion: Our results are comparable with those of the literature in term of survival without repetition, total survival and rate of acute and late complications. Our study highlights a relation between the volume of brachytherapy and the rate of late complications. Recent work showed an increase in local control when the amount of c brachytherapy increases, the brachytherapy will have in the future to be completed with optimization of the distribution of amount.
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Master thesis
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https://hal.univ-lorraine.fr/hal-01732326
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Submitted on : Wednesday, March 14, 2018 - 2:55:20 PM
Last modification on : Monday, October 19, 2020 - 11:09:57 AM
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  • HAL Id : hal-01732326, version 1

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Cédrik Lafond. Optimisation des techniques de radiothérapie dans le cadre de la prise en charge des patientes traitées par radiochimiothérapie d'un cancer du col de l'utérus. Sciences du Vivant [q-bio]. 2007. ⟨hal-01732326⟩

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