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Master thesis

Relations entre méthylation de l’ADN et facteurs de risque des pathologies liées au stress, pathologies cardio-vasculaires, infectieuses et mentales : une étude épidémiologique

Abstract : Gene expression is regulated by a wide range of mechanisms including endogenicmechanisms and external environmental factors. Epigenetic factors areconsidered to be the principal interface between the genome and theenvironment (Fraga, M 2005) (Szyf, M 2011a) (Szyf, M 2011b). Among thesemechanisms DNA methylation is probably the best understood. Moreover theDNA methylation pattern is susceptible to modifications induced byenvironmental factorsTaking into account its implication in the regulation of gene transcription andsilencing (Bird, A 2007), DNA methylation may also play a critical role in thedevelopment of various diseases including stress related disorders..The Department of Immunology of the “Centre de Recherche Public de la Santé”(CRP-Santé) in Luxembourg has gained considerable experience in clinicalstudies as well as in epigenetics, especially concerning stress response genes. Ihad the opportunity to pursue my Master internship in this Department workingon two academic exploratory studies projects related to the link between DNAmethylation and stress response.First, I was responsible for the data analysis of the “Cold Pressor Test” study.This study demonstrated the association between the stress response induced bya validated stress test: the Cold Pressor Test, and the methylation of theglucocorticoid receptor (GR) gene.These results, together with previous non clinical studies lead thePsychoImmunology team to design the “Long term epigenetic and physiologicaleffects of early life adversity” (EpiPath) study. EpiPath will examine the impact ofEarly Life Adversity (ELA) on the potential risk factors of major public healthproblems: cardiovascular, mental, immune system diseases and stress responsealterations. These are multifactorial diseases meaning that these conditionsdevelopment depends on the presence of genetics, epigenetics andenvironmental factors. The link between ELA and those pathologies in adulthoodis already settled and the aim of this present study is to provide a betterunderstanding of the impact of ELA on epigenetic methylation and on its clinicconsequences.
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https://hal.univ-lorraine.fr/hal-01732419
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Estelle Sandt. Relations entre méthylation de l’ADN et facteurs de risque des pathologies liées au stress, pathologies cardio-vasculaires, infectieuses et mentales : une étude épidémiologique. Sciences pharmaceutiques. 2014. ⟨hal-01732419⟩

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