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Master thesis

Etude des troubles du sommeil chez le patient parkinsonien: analyse rétrospective de 87 polysomnographies

Abstract : Methods : Retrospective review of medical records and polysomnography (PSG) in Parkinson disease or Parkinson syndrome patients. They were divided in 3 groups, according to the diagnosis given at the last follow-up visit : (1) Parkinson's disease (PD) without dementia (PDs; n =58), (2) PD plus dementia or Lewy body demantia (PDp; n = 15), (3) various PS syndromes (PSv, n = 14). This group included progressive supranuclear palsy (n = 5), multiple system atrophy (n = 6), and unclassified PS (n = 3). A subanalysis was performed on PDs patients who converted to PDp within the follow up period (n = 7). Another subanalysis was performed on PDs patients comparing disease duration. Results : the patients with PDp performed less well on all the sleep parameters, when compared with the other groups. However, the difference was only significiant for presence of sleep apnea syndrome (SAS) (p=0.01) and borderline significiant for sleep efficiency (0.05). PDp patients were also older (p=0.01) and had more visual hallucinations (VH)(p<0.001). There was no significiant relationship between VH and REM sleep behaviour disorder (RBD). Conversion from PDS to PDp was unpredictable by PSG parameters. We didn't find a link betwwen daytime sleepiness and nocturnal sleep quality. SAS, RBD, periodic limb movements were not linked to disease duration. Conclusion : Polysomnographic abnormalities are unable to reliably distinguish between different PS syndromes, at least in medicated patients with a medium duration of the disease. They can also not predict conversion to a dementia syndrome, although most pronounced in Parkinsonian patients with dementia. These findings emphasize that sleep disturbances are an integral part of all PS syndromes.
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Master thesis
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Submitted on : Wednesday, March 14, 2018 - 3:04:31 PM
Last modification on : Friday, July 22, 2022 - 1:18:34 PM
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  • HAL Id : hal-01732511, version 1


Nadine Jacoby. Etude des troubles du sommeil chez le patient parkinsonien: analyse rétrospective de 87 polysomnographies. Sciences du Vivant [q-bio]. 2008. ⟨hal-01732511⟩



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