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Master thesis

Facteurs prédictifs de thrombose inopinée du filtre en hémofiltration veino-veineuse continue pédiatrique

Abstract : Premature clotting of the filter during continuous renal replacement therapy is one of the most frequent adverse event observed. Consequences are deleterious treatment interruptions, blood loss for the patient, and increased costs for the medical service. We studied data of 21 patients of the Pediatric Intensive Care Unit of Nancy's Children Hospital, in order to highlight risk factors of early circuit's coagulation and to determine a coefficient of filter thrombosis, which could be a predictive parameter of the machine?s breakdown. Our coefficient of filterthrombosis, calculated using the pressions indicated by the device and the patient'shematocrit, which reflects blood viscosity, was not sufficiently relevant. However, the patient's weight, the blood flow and especially the filtration fraction strongly influenced the duration of filter operating time in our sample. The main determinant of the circuit's life shortening in our study seems to be the settings of the hemofiltration machine by the physician, settings leading to a too low blood flow or an excessive filtration fraction. This event occured more frequently for patients of low weight, particularly vulnerable to the complications of these treatements
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Master thesis
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Submitted on : Wednesday, March 14, 2018 - 3:17:46 PM
Last modification on : Friday, October 23, 2020 - 4:58:51 PM
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Noémie Berlengi. Facteurs prédictifs de thrombose inopinée du filtre en hémofiltration veino-veineuse continue pédiatrique. Sciences du Vivant [q-bio]. 2011. ⟨hal-01732768⟩



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