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Master thesis

Le curage ganglionnaire lombo-aortique dans la prise en charge des cancers épithéliaux des ovaires : évaluation des pratiques au Centre Alexis Vautrin

Abstract : Objectives: the purpose of our study was to evaluate the morbidity and benefits of lumboaortic lymphadenectomy in the management of epithelial ovarian cancers.Methods: our study is a retrospective study. It includes 136 patients who had undergone a lumbo-aortic lymphadenectomy between 1992 and 2010. We have separated two types of lymphadenectomy depending on the extension of the surgery: the first one, called "bilateral", included the resection of three groups of nodes (para-aortic, inter-aortico-caval and paracaval), the other group, called "unilateral", consisted on the resection of one or two of these nodal groups. The progression-free survival and the overall survival have been compared to those of patients who did not have lumbo-aortic lymphadenectomy (data obtained from the hospital of Nantes).Results: the mean age of our patients was 54,7 years. We found a significant difference in the number of resected and metastatic nodes between the "bilateral" and the "unilateral" groups. There was no difference between these two groups for: demographic data, surgical data, morbidity and survivals. The comparison between the patients with lumbo-aortic lymphadenectomy and those without showed longer progression-free and overall survivals (p= 0,000289 and p= 0,00000397).Conclusions: the surgical techniques and indications of retroperitoneal lymphadenectomy inthe management of epithelial ovarian cancers should be clarified in order to improve andhomogenize this surgery. The main goal remains the achievement of a maximalcytoreduction and the management of these cancers by experimented medical andparamedical teams
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Frédérique Mohammadi-Kuehn. Le curage ganglionnaire lombo-aortique dans la prise en charge des cancers épithéliaux des ovaires : évaluation des pratiques au Centre Alexis Vautrin. Sciences du Vivant [q-bio]. 2011. ⟨hal-01733262⟩

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