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Master thesis

Prevalence of dactylitis in the spondyloarthropathies: a systematic review of the literature and

Abstract : Background: Dactylitis is frequently related to spondyloarthropathies (SpA), especially in case of psoriatic arthritis or reactive arthritis. But to date, its prevalence is not well established.Objectives: To evaluate the prevalence of dactylitis in SpA.Methods: A systematic literature search was performed in the Pubmed Medline database. In addition, baseline data from randomized controlled trials in the Pubmed Medline database were included. Case reports or studies with less than 30 patients were excluded. The prevalence of clinical dactylitis in SpA was calculated using the method of the inverse of the variance, with random effects, on the logit transformed proportions.Results: Among the 449 articles selected by the search, 35 articles concerned adults SpA (6692 patients, mean age 45.2±12.8 calculated on 4892 available data, sex ratio M/F 1.53 calculated on 5913 available data, ankylosing spondylitis 13.9%, reactive arthritis 3.1%, psoriatic arthritis 66.4%, arthritis associated with inflammatory bowel disease 0.8%, undifferentiated SpA 15.8%) and 5 articles concerned juvenile psoriatic arthritis (JSpA) (320 patients, sex ratio 0.67) alloweda calculation of the prevalence of dactylitis in SpA and in JPsA. HLA B27 was present in 1505/2501 adult patients with available data (60.2%) and in 29/320 JPsA (9.1%). The pooled prevalence of dactylitis was 24.2% (95% CI 19.8 to 29.2%), and after using Egger?s test and trim and fill method, adjusted value was 36.4% (95% CI 30.3 to 43%). The pooled prevalence varied with the type of SpA: ankylosing spondylitis 4.6% (95% CI 2.4 to 8.7%), reactive arthritis 26%(95% CI 16 to 39.3%), psoriatic arthritis 30.4% (95% CI 25.7 to 35.5%), and after using Egger?s test and trim and fill method, adjusted value was 41.8% (95% CI 35.8 to 48.1%), arthritis associated with inflammatory bowel disease 0% and undifferentiated SpA 8.2% (95% CI 2.5 to 23.5%), JPsA 37.3% (95% CI 32.1 to 42.7%).Conclusion: The prevalence of clinical dactylitis is more frequent in psoriatic arthritis and reactive arthritis in the literature than in the others types of SpA
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Master thesis
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https://hal.univ-lorraine.fr/hal-01739178
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  • HAL Id : hal-01739178, version 1

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Florain Sibille. Prevalence of dactylitis in the spondyloarthropathies: a systematic review of the literature and. Life Sciences [q-bio]. 2011. ⟨hal-01739178⟩

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