L'acide hyaluronique : Production microbiologique et applications

Abstract : Hyaluronic acid is a natural polymer, found in many animal and microbial species, which has remarkable physical and chemical properties. For nearly thirty years, it is becoming increasingly popular in the therapeutic and cosmetics areas. To meet the ever increasing demand in this biopolymer, obtaining pathways have evolved with scientific knowledges. The extraction from animal tissue has been replaced with microbial production. The strains used to obtain this molecule are bacteria of the genus Streptococcus with a capsule, especially the species Streptococcus equi subsp. zooepidemicus.Optimization of culture medium and culture conditions, functions of strain and selected mode, allows to obtain the most important concentration of high molecular weight hyaluronic acid. In order to ensure quality control of the product, hyaluronic acid must meet the standards of the European Pharmacopoeia. These multiple controls as well as tolerance and absorbable property of hyaluronic acid make it a product with limited side effects that occupies a prominent place in the search for the ideal filler.
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Master thesis
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Mathieu Poinsot. L'acide hyaluronique : Production microbiologique et applications. Sciences pharmaceutiques. 2011. ⟨hal-01764996⟩

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