We performed an interlaboratory comparison study with the aim to determine the accuracy of cosmogenic 21Ne measurements in quartz. CREU-1 is a natural quartz standard prepared from amalgamated vein clasts which were crushed, thoroughly mixed, and sieved into 125–250 μm and 250–500 μm size fractions. 50 aliquots of CREU-1 were analyzed by five laboratories employing six different noble gas mass spectrometers. The released gas contained a mixture of 16–30% atmospheric and 70–84% non-atmospheric (predominantly cosmogenic) 21Ne, defining a linear array on the 22Ne/20Ne-21Ne/20Ne three isotope diagram with a slope of 1.108 ± 0.014. The internal reproducibility of the measurements is in good agreement with the formal analytical precision for all participating labs. The external reproducibility of the 21Ne concentrations between labs, however, is significantly overdispersed with respect to the reported analytical precision. We report an average reference concentration for CREU-1 of 348 ± 10 × 106 at [21Ne]/g[SiO2], and suggest that the 7.1% (2σ) overdispersion of our measurements may be representative of the current accuracy of cosmogenic 21Ne in quartz. CREU-1 was tied to CRONUS-A, which is a second reference material prepared from a sample of Antarctic sandstone. We propose a reference value of 320 ± 11 × 106 at/g for CRONUS-A. The CREU-1 and CRONUS-A intercalibration materials may be used to improve the consistency of cosmogenic 21Ne to the level of the analytical precision.