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Conference Papers Year : 2017

Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?

Abstract

Thanks to their immune properties, the mesenchymal stem cells (MSC) are a promising source for cell therapy. Current clinical trials show that MSC administrated to patients can treat different diseases (graft-versus-host disease (GVHD), liver cirrhosis, systemic lupus, erythematosus, rheumatoid arthritis, type I diabetes…). In this case, the most common mode of cell administration is the intravenous injection, and the hemodynamic environment of cells induced by blood circulation could interfere on their behavior during the migration and homing towards the injured site. After a brief review of the mechanobiology concept, this paper will help in understanding how the mechanical environment could interact with MSC behavior once they are injected to patient in cell-based treatment.
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Dates and versions

hal-01777759 , version 1 (25-04-2018)

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Céline Huselstein, R. Rahouadj, N. de Isla, D. Bensoussan, J. Stoltz, et al.. Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?. The 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Jul 2016, nancy, France. pp.S47 - S56, ⟨10.3233/BME-171623⟩. ⟨hal-01777759⟩
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