Image segmentation is a widely used in medical imaging applications by detecting anatomical structures and regions of interest. This paper concerns a survey of numerous segmentation model used in biomedical field. We organized segmentation techniques by four approaches, namely, thresholding, edge-based, region-based and snake. These techniques have been compared with simulation results and demonstrated the feasibility of medical image segmentation. Snake was demonstrated a capability with a high performance metrics to detect irregular shape as carcinoma cell type. This study showed the advantage of the deformable segmentation technique to segment abnormal cells with Dice similarity value over 83%.