Responsiveness in manufacturing is a key challenge for facing open-ended changes more and more enhanced by the increasing development of easy-to-use digital technologies. However, the control of a given situation into wholeness by a respondent system is raising design issues to make cooperating together the many entities of the Human, digital and physical parts interleaved in a related world-of-interest in order to reach and maintain common goals. This paper provides an overview of some relevant works for attaining a situated perspective of the responsiveness of a system to be engineered with simplexity. This property of living beings is more particularly explored for the cognitive orchestration of the interdisciplinary knowledge assets, which are cooperatively involved in a project system in order to frame a given situation examined with a system perspective.