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Master thesis

Rôle de la sarcopénie mesurée en imagerie en coupe comme facteur de risque indépendant de décés chez les patients porteurs d'un adénocarcinome pancréatique

Résumé : Our purpose was to evaluate sarcopenia as an independent prognostic factor for overall survival in patients with pancreatic adenocarcinoma to predict early relapses or progressive disease and to help decision-making between chemotherapy maintenance and supportive care treatment only. From January 2009 to December 2015, all the patients in our center who underwent at least one chemotherapy against pancreatic adenocarcinoma were retrieved (N=114). A retrospective review of the total psoas area (TPA) was performed for each available scan (N=713). The TPA was measured on a single cross-sectional image through the third lumbar vertebrae normalized for stature [TPA (mm2)/height (m2)]. The TPA variation (the percentage decrease in the value of the TPA during the follow-up) was also analyzed. A TPA level under 420 during the follow-up whatever the time of the measure was an independent prognostic factor of death HR=3.419 ([2.168;5.394]; 95% CI; p<0.0001) and a TPA decrease of more than 20% from baseline was also an independent prognostic factor of death HR=7.169 ([4.526;11.353]; 95% CI; p<0.0001). The multivariate analysis confirmed the results with HR=5.799 ([3.418; 9.839]; 95% CI; p<0.0001) in the non-surgical group and HR=8.089 ([2.157; 30.339]; 95% CI; p=0.0019) in the surgical group for TPA decrease of more than 20% from baseline during the follow-up. Our analysis shows that regardless of the time of the measurement, a TPA value under 420 and a TPA decrease of more than 20% during the follow-up are strong and independent death risk prognostic factors in patients with pancreatic adenocarcinoma..
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https://hal.univ-lorraine.fr/hal-01932218
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Submitted on : Friday, November 23, 2018 - 8:44:47 AM
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  • HAL Id : hal-01932218, version 1

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Aurélien Lambert. Rôle de la sarcopénie mesurée en imagerie en coupe comme facteur de risque indépendant de décés chez les patients porteurs d'un adénocarcinome pancréatique. Sciences du Vivant [q-bio]. 2016. ⟨hal-01932218⟩

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