Skip to Main content Skip to Navigation
Journal articles

General methodology for the chemoselective N-alkylation of (2,2,6,6)-tetramethylpiperidin-4-ol: Contribution of microwave irradiation

Abstract : A convenient method to access a broad variety of N-alkyl-(2,2,6,6)-tetramethylpiperidin-4-ol compounds is reported. The thermal treatment of a mixture of (2,2,6,6)-tetramethylpiperidin-4-ol and allyl or benzyl bromide derivatives gave the corresponding N–alkylated compounds in good yields while leaving the hydroxyl functional group intact. Whereas 40 h were needed to reach complete conversion, microwave irradiation allowed the reaction time to be reduced (20 min) and improved the yields in most cases.
Document type :
Journal articles
Complete list of metadatas

Cited literature [26 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/hal-01969189
Contributor : Alexandre Vasseur <>
Submitted on : Monday, March 23, 2020 - 10:59:51 AM
Last modification on : Monday, March 23, 2020 - 12:43:30 PM

File

RM_2019.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Romain Membrat, Alexandre Vasseur, Laurent Giordano, Alexandre Martinez, Didier Nuel. General methodology for the chemoselective N-alkylation of (2,2,6,6)-tetramethylpiperidin-4-ol: Contribution of microwave irradiation. Tetrahedron Letters, Elsevier, 2019, 60 (3), pp.240-243. ⟨10.1016/j.tetlet.2018.12.020⟩. ⟨hal-01969189⟩

Share

Metrics

Record views

346

Files downloads

700