Sequence Analysis of env C2/V3, gag p17/p24, and pol Protease Regions of 25 HIV Type 1 Isolates from Ho Chi Minh City, Vietnam

Abstract : Env C2/V3, gag p17/p24, pol protease, and RT regions of HIV-1 isolates recently obtained from 25 HIV-1 seropositive individuals from Ho Chi Minh City (Vietnam) were studied, and genes subtypes were determined by DNA sequence analyses. Twenty-three isolates out of 25 were identified as belonging to subtype E, now recognized as circulating recombinant form 1 (CRF01_AE). The motif at the top of the V3 loop (generally GPGQ) was then preceded by an isoleucine or a methionine (M) residue; the M residue might be a local signature of Vietnamese E isolates compared to Thai E viruses. Two isolates (8%) were shown to be intersubtype recombinants: one E/B and one CRF02_AG(IBNG)/D. The polymorphism of pol protease was considered only for CRF01_AE isolates and is clearly different from that recorded for B viruses with substitutions at positions 13, 35, 36, 41, 69, and 89.
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https://hal.univ-lorraine.fr/hal-02014617
Contributor : Evelyne Schvoerer <>
Submitted on : Monday, February 11, 2019 - 4:30:41 PM
Last modification on : Sunday, February 24, 2019 - 1:29:42 AM

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Anne Caumont, Nguyen Thi Hoang Lan, Nguyen Thi Vy Uyen, Pham Van Hung, Evelyne Schvoerer, et al.. Sequence Analysis of env C2/V3, gag p17/p24, and pol Protease Regions of 25 HIV Type 1 Isolates from Ho Chi Minh City, Vietnam. AIDS Research and Human Retroviruses, Mary Ann Liebert, 2001, 17 (13), pp.1285-1291. ⟨10.1089/088922201750461357⟩. ⟨hal-02014617⟩

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