The enigma of caspase-2: the laymen's view

Abstract : Proteolysis of cellular substrates by caspases (cysteine-dependent aspartate-specific proteases) is one of the hallmarks of apoptotic cell death. Although the activation of apoptotic caspases is considered a 'late-stage' event in apoptosis signaling, past the commitment stage, one caspase family member, caspase-2, splits the cell death community into half-those searching for evidence of an apical initiator function of this molecule and those considering it as an amplifier of the apoptotic caspase cascade, at best, if relevant for apoptosis at all. This review screens past and present biochemical as well as genetic evidence for caspase-2 function in cell death signaling and beyond.
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-02088205
Contributor : Bénédicte Sohm <>
Submitted on : Tuesday, April 2, 2019 - 4:25:08 PM
Last modification on : Friday, April 5, 2019 - 11:36:06 AM

Links full text

Identifiers

Collections

Citation

G Krumschnabel, B. Sohm, F Bock, C Manzl, A Villunger. The enigma of caspase-2: the laymen's view. Cell Death and Differentiation, Nature Publishing Group, 2008, ⟨10.1038/cdd.2008.170⟩. ⟨hal-02088205⟩

Share

Metrics

Record views

13