Article Dans Une Revue ACS Medicinal Chemistry Letters Année : 2019

Dendrigraft of Poly- l -lysine as a Promising Candidate To Reverse Heparin-based Anticoagulants in Clinical Settings

Résumé

By using a combination of experimental and computational experiments, we demonstrated that a second-generation dendrigraft of poly-L-lysine neutralizes the anticoagulant activity of unfractionated heparin, low-molecular-weight heparin, and fondaparinux more efficiently than protamine does in human plasma, making this synthetic polymer a promising surrogate of this problematic protein in clinical settings.

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hal-02188219 , version 1 (18-07-2019)

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Benjamin Ourri, Jean-Patrick Francoïa, Gerald Monard, Jean-Christophe Gris, Julien Leclaire, et al.. Dendrigraft of Poly- l -lysine as a Promising Candidate To Reverse Heparin-based Anticoagulants in Clinical Settings. ACS Medicinal Chemistry Letters, 2019, 10 (6), pp.917-922. ⟨10.1021/acsmedchemlett.9b00090⟩. ⟨hal-02188219⟩
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