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How to facilitate psychosocial adjustment in women tested for hereditary breast or ovarian cancer susceptibility? Insights from network analysis

Abstract : Background:Increasingly complex genetics counseling requires guidance to facilitatecounselees' psychosocial adjustment. We explored networks of inter-relationshipsamong coping strategies and specific psychosocial difficulties in women tested forhereditary breast or ovarian cancer.Methods:Of 752 counselees consecutively approached, 646 (86%) completed ques-tionnaires addressing coping strategies (Brief-COPE) and psychosocial difficulties(PAHC) after the initial genetic consultation (T1), and 460 (61%) of them again afterthe test result (T2). We applied network analysis comparing partial correlationsamong these questionnaire scales, according to the type of genetic test - single gene-targeted or multigene panel, test result and, before and after testing.Results:Overall, 98 (21.3%), 259 (56.3%), 59 (12.8%) and 44 (9.6%) women receiveda pathogenic variant, uninformative negative (panel testing), variant of uncertain sig-nificance (VUS) or true negative (targeted testing) result, respectively. In most net-works, connections were strongest between avoidance and general negativeemotions. Cognitive restructuring was inter-related to lower psychosocial difficulties.Avoidance and familial/social relationship difficulties were strongly related in womenreceiving a pathogenic variant. Stronger inter-relationships were also noticedbetween avoidance and worries about personal cancer and concerns about heredi-tary predisposition in women receiving a VUS result. Differences in the prominenceof inter-relationships were observed by type of testing and assessment time.Conclusions:Network analysis may be fruitful to highlight prominent inter-relationships among coping strategies and psychosocial difficulties, in women testedfor HBOC susceptibility, offering guidance for counseling.
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https://hal.univ-lorraine.fr/hal-02275325
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Submitted on : Friday, August 30, 2019 - 4:07:03 PM
Last modification on : Friday, August 5, 2022 - 11:57:38 AM

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Anne Brédart, Julia Dick, Alejandra Cano, Robieux Léonore, Antoine de Pauw, et al.. How to facilitate psychosocial adjustment in women tested for hereditary breast or ovarian cancer susceptibility? Insights from network analysis. Psycho-Oncology, Wiley, 2020, 29 (3), pp.550-556. ⟨10.1002/pon.5302⟩. ⟨hal-02275325⟩

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