In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different þ- Lactam Resistance Phenotypes

The study evaluated the in vitro activity of ceftolozane-tazobactam (C/T) against 94 unique clinical isolates of Enterobacter cloacae complex (ECC). No difference was observed according to the ECC cluster. The in vitro activity greatly varied depending on the þ-lactamase-producing proﬁle: 100%, 67%, and 19% of wild-type, extended- spectrum þ-lactamase (ESBL)-producing, and AmpC-overproducing strains, respectively, were susceptible to C/T. The use of C/T could be of interest for the treatment of some infections caused by ESBL-producing AmpCnonoverexpressing ECC isolates.

Mots clés

ESBL TOL-TAZ tazobactam ceftolozane ECC E. cloacae complex AmpC

Domaines

Psychologie

Fichier principal

In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different þ-Lactam Resistance Phenotypes (fait).pdf (236.84 Ko)

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Romain Lebreuilly : Connectez-vous pour contacter le contributeur

https://hal.univ-lorraine.fr/hal-02313665

Soumis le : vendredi 11 octobre 2019-14:25:54

Dernière modification le : jeudi 17 octobre 2024-10:52:03

Dates et versions

hal-02313665 , version 2 (20-09-2018)

hal-02313665 , version 1 (11-10-2019)

Identifiants

HAL Id : hal-02313665 , version 1
DOI : 10.1128/AAC.00675-18

Citer

Frédéric Robin, Michel Auzou, Richard Bonnet, Romain Lebreuilly, Christophe Isnard, et al.. In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different þ- Lactam Resistance Phenotypes. Antimicrobial Agents and Chemotherapy, 2018, 62 (9), ⟨10.1128/AAC.00675-18⟩. ⟨hal-02313665v1⟩

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