Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017
Toby Smith
,
Michael Mansfield
,
Gillian Hawker
(1)
,
David R. Hunter
(2)
,
Lyn March
(3)
,
Maarten Boers
(4)
,
Beverley Shea
,
Robin Christensen
(5)
,
Francis Guillemin
(1, 6)
,
Caroline Terwee
(7)
,
Paula Williamson
,
Ewa Roos
(8)
,
Richard Loeser
,
Thomas Schnitzer
,
Margreet Kloppenburg
(9)
,
Tuhina Neogi
,
Christoph Ladel
,
Gurdyal Kalsi
,
Ulrike Kaiser
,
Thomas Buttel
,
Anne Ashford
,
Ali Mobasheri
(10)
,
Nigel Arden
(11)
,
Alan Tennant
,
Marc Hochberg
(12)
,
Maarten J. de Wit
(4)
,
Peter Tugwell
(13)
,
Philip Conaghan
(14)
1
CIC-EC -
Centre d'investigation clinique - Epidémiologie clinique [Nancy]
2 Department of Statistics, Penn State University
3 Institute of Bone & Joint Research
4 VU University Medical Center [Amsterdam]
5 The Parker Institute
6 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
7 EMGO Institute Health and Care Research
8 SDU - University of Southern Denmark
9 Department of Rheumatology and Clinical Epidemiology, Leiden University Medical Center (LUMC)
10 School of Veterinary Medicine and Science
11 University of Oxford
12 Medical Care Clinical Center [Baltimore, MD, USA]
13 University of Ottawa [Ottawa]
14 Section of Musculoskeletal Diseasee
2 Department of Statistics, Penn State University
3 Institute of Bone & Joint Research
4 VU University Medical Center [Amsterdam]
5 The Parker Institute
6 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
7 EMGO Institute Health and Care Research
8 SDU - University of Southern Denmark
9 Department of Rheumatology and Clinical Epidemiology, Leiden University Medical Center (LUMC)
10 School of Veterinary Medicine and Science
11 University of Oxford
12 Medical Care Clinical Center [Baltimore, MD, USA]
13 University of Ottawa [Ottawa]
14 Section of Musculoskeletal Diseasee
Toby Smith
- Function : Author
Michael Mansfield
- Function : Author
Beverley Shea
- Function : Author
Francis Guillemin
- Function : Author
- PersonId : 751733
- IdHAL : francis-guillemin
- ORCID : 0000-0002-9860-7024
Paula Williamson
- Function : Author
Richard Loeser
- Function : Author
Thomas Schnitzer
- Function : Author
Tuhina Neogi
- Function : Author
Christoph Ladel
- Function : Author
Gurdyal Kalsi
- Function : Author
Ulrike Kaiser
- Function : Author
Thomas Buttel
- Function : Author
Anne Ashford
- Function : Author
Ali Mobasheri
- Function : Author
- PersonId : 765463
- ORCID : 0000-0001-6261-1286
- IdRef : 125244592
Alan Tennant
- Function : Author
Peter Tugwell
- Function : Author
- PersonId : 791626
- ORCID : 0000-0001-5062-0556
- IdRef : 081376324
Abstract
OBJECTIVE: To assess the uptake of the OMERACT-OARSI (Outcome Measures in Rheumatology- Osteoarthritis Research Society International) core outcome set (COS) domains in hip and/or knee osteoarthritis (OA) trials.
METHODS: There were 382 trials of hip and/or knee OA identified from the ClinicalTrial.gov registry from 1997 to 2017. Frequency of COS adoption was assessed by year and per 5-yearly phases.
RESULTS: COS adoption decreased from 61% between 1997 and 2001 to 38% between 2012 and 2016. Pain (95%) and physical function (86%) were most consistently adopted. Patient's global assessment (48%) was the principal missing domain.
CONCLUSION: Limited adoption of the COS domains indicates that further consideration to improve uptake is required.