Invasive Pulmonary Aspergillosis treatment duration in haematology patients in Europe: an EFISG, IDWP‐EBMT, EORTC‐IDG, SEIFEM survey - Université de Lorraine Access content directly
Journal Articles Mycoses Year : 2020

Invasive Pulmonary Aspergillosis treatment duration in haematology patients in Europe: an EFISG, IDWP‐EBMT, EORTC‐IDG, SEIFEM survey

1 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals
2 Service des Maladies infectieuses et tropicales [CHU Necker]
3 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
4 University of Cologne
5 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
6 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
7 Nicolaus Copernicus University [Toruń]
8 UNIGE - Université de Genève = University of Geneva
9 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
10 Service des Maladies Infectieuses et Tropicales [CHRU Nancy]
11 University Hospitals Leuven [Leuven]
12 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
13 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
14 Erasmus MC - Erasmus University Medical Center [Rotterdam]
15 Statens Serum Institut [Copenhagen]
16 UCPH - University of Copenhagen = Københavns Universitet
17 Rigshospitalet [Copenhagen]
18 INSA - Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]
19 Oslo University Hospital [Oslo]
20 North-Western State Medical University [St Petersburg, Russia]
21 Hacettepe University = Hacettepe Üniversitesi
22 University of Belgrade [Belgrade]
23 NKUA - National and Kapodistrian University of Athens
24 Karolinska University Hospital [Stockholm]
25 IRFAC - Inserm U1113 - Interface de Recherche Fondamentale et Appliquée en Cancérologie
26 Radboud University Medical Center [Nijmegen]
27 University Hospital of Cologne [Cologne]
28 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck


Background : Invasive pulmonary aspergillosis (IPA) optimal duration of antifungal treatment is not known.Objectives : In a joint effort, four international scientific societies/groups performed a survey to capture current practices in European hematology centers regarding management of IPA.Methods : We conducted in 2017 a cross‐sectional internet‐based questionnaire survey to assess practices in sixteen European countries concerning IPA management in hematology patients including tools to evaluate treatment response, duration and discontinuation. The four groups/societies European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG), Infectious Diseases Working Party‐European Society for Blood and Bone Marrow Transplantation (IDWP‐EBMT), European Organisation for Research and Treatment‐Infectious Disease group (EORTC‐IDG) and Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM) were involved in the project.Results : 112 physicians from 14/16 countries answered the survey. Galactomannan antigen was available in serum and bronchoalveolar lavage in most centers (106/112 (95%) and 97/112 (87%) respectively), quantitative Aspergillus spp. PCR in 27/112 (24%) centres, β‐D‐glucan in 24/112 (21%) and positron emission tomography in 50/112 (45%). Treatment duration differed between haematological malignancies, with a median duration of 6 weeks [IQR 3‐12] for patients with AML, 11 [4‐12] for patients with allogenic stem cell transplantation and GvHD and 6 [3‐12] for patients with lymphoproliferative disease. Treatment duration significantly differed according to country.Conclusion : Essential IPA biomarkers are not available in all European countries and treatment duration is highly variable according to country. It will be important to provide guidelines to help with IPA treatment cessation with algorithms according to biomarkers availability.
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Dates and versions

hal-02474197 , version 1 (11-02-2020)



F. Lanternier, D Seidel, L. Pagano, J Styczynski, M Mikulska, et al.. Invasive Pulmonary Aspergillosis treatment duration in haematology patients in Europe: an EFISG, IDWP‐EBMT, EORTC‐IDG, SEIFEM survey. Mycoses, 2020, 63 (5), pp.420-429. ⟨10.1111/myc.13056⟩. ⟨hal-02474197⟩
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