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Trans-to-cis photoisomerization of cyclocurcumin in different environments rationalized by computational photochemistry

Abstract : Cyclocurcumin is a turmeric component that attracted much less attention compared to the well known curcumin. In spite of the less deep charcaterization of its properties, cyclocurcumin has shown promising anticancer effects when used in combination with curcumin. Especially, due to its peculiar molecular structure, cyclocurcumin can be regarded as an almost ideal photoswitch, whose capabilities can also be exploited for relevant biological applications. Here, by means of state-of-the-art computational methods for electronic excited-state calculations (TD-DFT, MS-CASPT2, XMS-CASPT2) we analyze in detail the absorption and photoisomerization pathways leading from the more stable trans isomer to the cis one. The different molecular surroundings, taken into account by means of electrostatic solvent effect and compared with available experimental data, have been found to be critical in describing the fate of irradiated cyclocurcumin: while in non-polar environments an excited state barrier prevents photoisomerization and favours fluorescence, in polar solvents an almost barrierless path results in a strikingly decrease of fluorescence, opening the way toward a crossing region with the ground state and thus funneling the photoproduction of the cis isomer.
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https://hal.univ-lorraine.fr/hal-02476342
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Submitted on : Wednesday, February 12, 2020 - 3:59:09 PM
Last modification on : Friday, October 16, 2020 - 4:16:02 PM
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Marco Marazzi, Antonio Francés-Monerris, Maxime Mourer, Andreea Pasc, Antonio Monari. Trans-to-cis photoisomerization of cyclocurcumin in different environments rationalized by computational photochemistry. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2020, 22, pp.4749-4757. ⟨10.1039/c9cp06565b⟩. ⟨hal-02476342⟩

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