Effects of metabolic syndrome on arterial function in different age groups: the Advanced Approach to Arterial Stiffness study
Jirar Topouchian
(1)
,
Carlos Labat
(2)
,
Sylvie Gautier
(3)
,
Magnus Bäck
(2, 4)
,
Apostolos Achimastos
(5)
,
Jacques Blacher
(1)
,
Marcin Cwynar
(6)
,
Alejandro de La Sierra
(7)
,
Denes Pall
(8)
,
Francesco Fantin
(9)
,
Katalin Farkas
(10)
,
Luis Garcia-Ortiz
(11, 12)
,
Zoya Hakobyan
(13)
,
Piotr Jankowski
(14)
,
Ana Jelakovic
(15)
,
Zhanna Kobalava
(16)
,
Alexandra Konradi
(17)
,
Yulia Kotovskaya
(16, 18)
,
Marina Kotsani
(19)
,
Irina Lazareva
(20)
,
Alexander Litvin
(21)
,
Viktor Milyagin
(22)
,
Iveta Mintale
(23)
,
Oscar Persson
(4)
,
Rafael Ramos
,
Anatoly Rogoza
,
Ligita Ryliskyte
,
Angelo Scuteri
,
Yuriy Sirenko
,
Georges Soulis
,
Nebojsa Tasic
,
Maryna Udovychenko
,
Saule Urazalina
,
Peter Wohlfahrt
,
Parounak Zelveian
,
Athanase Benetos
(2, 3)
,
Roland Asmar
(24)
1
Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris]
2 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
3 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
4 Karolinska University Hospital [Stockholm]
5 NKUA - National and Kapodistrian University of Athens
6 Jagiellonian University - Medical College
7 Hospital Universitario Mutua de Terrassa
8 University of Debrecen
9 UNIVR - Università degli studi di Verona = University of Verona
10 University of Budapest
11 IBSAL - Instituto de Investigación Biomédica de Salamanca
12 Universidad de Salamanca [España] = University of Salamanca [Spain]
13 Yerevan State University
14 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
15 University Hospital Centre Zagreb and University of Zagreb School of Medicine
16 RUDN University - People's Friendship University of Russia [Moscow] = Rossijskij universitet družby narodov [Moskva]
17 Almazov National Medical Research Centre (St. Petersburg)
18 Pirogov Russian National Reasearch Medical University Moscow
19 Service de Gériatrie [CHRU Nancy]
20 Republican Scientific and Practice Centre Cardiology, Minsk
21 Russian Cardiology Research and Production Complex
22 Université d'État de Smolensk
23 RSU - Riga Stradins University
24 INSERM - Institut National de la Santé et de la Recherche Médicale
2 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
3 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
4 Karolinska University Hospital [Stockholm]
5 NKUA - National and Kapodistrian University of Athens
6 Jagiellonian University - Medical College
7 Hospital Universitario Mutua de Terrassa
8 University of Debrecen
9 UNIVR - Università degli studi di Verona = University of Verona
10 University of Budapest
11 IBSAL - Instituto de Investigación Biomédica de Salamanca
12 Universidad de Salamanca [España] = University of Salamanca [Spain]
13 Yerevan State University
14 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
15 University Hospital Centre Zagreb and University of Zagreb School of Medicine
16 RUDN University - People's Friendship University of Russia [Moscow] = Rossijskij universitet družby narodov [Moskva]
17 Almazov National Medical Research Centre (St. Petersburg)
18 Pirogov Russian National Reasearch Medical University Moscow
19 Service de Gériatrie [CHRU Nancy]
20 Republican Scientific and Practice Centre Cardiology, Minsk
21 Russian Cardiology Research and Production Complex
22 Université d'État de Smolensk
23 RSU - Riga Stradins University
24 INSERM - Institut National de la Santé et de la Recherche Médicale
Carlos Labat
- Fonction : Auteur
- PersonId : 780990
- ORCID : 0000-0002-5275-3405
Jacques Blacher
- Fonction : Auteur
- PersonId : 1065011
Rafael Ramos
- Fonction : Auteur
Anatoly Rogoza
- Fonction : Auteur
Ligita Ryliskyte
- Fonction : Auteur
Angelo Scuteri
- Fonction : Auteur
Yuriy Sirenko
- Fonction : Auteur
Georges Soulis
- Fonction : Auteur
Nebojsa Tasic
- Fonction : Auteur
Maryna Udovychenko
- Fonction : Auteur
Saule Urazalina
- Fonction : Auteur
Peter Wohlfahrt
- Fonction : Auteur
Parounak Zelveian
- Fonction : Auteur
Athanase Benetos
- Fonction : Auteur
- PersonId : 764721
- ORCID : 0000-0002-5197-1515
Résumé
OBJECTIVE:
The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied.
METHODS:
This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health & Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid-femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40-49, 50-59, 60-74, 75-90 years. In this report, we present the baseline data of this study.
RESULTS:
Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P < 0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r = 0.06, P < 0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57 ± 0.06 vs. 8.65 ± 0.10, P < 0.001; CAVI: 8.34 ± 0.03 vs. 8.29 ± 0.04, P = 0.40; mean ± SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV.
CONCLUSION:
This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF-PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.
