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Human cryptosporidiosis in immunodeficient patients in France (2015–2017)

Damien Costa 1 Romy Razakandrainibe 2 Marc Sautour 3 Stéphane Valot 4 Louise Basmaciyan 5 Gilles Gargala 6 Loïc Favennec 7 Frédéric Dalle Anne Debourgogne 8, 9 Adela Angoulvant 10 Patrice Agnamey 11 Julie Bonhomme 12 Brigitte Degeilh 13 Cathy Chemla 14 Cécile Garnaud 15 Coralie Lollivier 16 Cécile Angebault 17 Pascal Delaunay 18 Guillaume Desoubeaux 19 Emilie Frealle 20 Frédéric Grenouillet 21 Florent Morio 22 Françoise Botterel 23 Ghania Belkadi 16 Hélène Yera 24 Gilles Nevez 25 Xavier Iriart 26 Isabelle Accoceberry 27 Julie Brunet 28 Marc Thellier 29 Denis Lemeteil 1 Meja Rabodonirina 30 Milène Sasso 31 Charline Miossec 32 Murielle Nicolas 16 Nicole Desbois 33 Philippe Poirier 34 Christelle Pomares 5 Sandrine Houzé 35 Yohann Le Govic 16 Anne Pauline Bellanger 36 Franck Labbe 16 Marie Laure Dardé 37 Olivier Duquesnoy 16 Pierre Flori 38 Patrick Bastien 31 Thomas Gueudet 39 Isabelle Villena 40 Dominique Aubert 41 Estelle Cateau 42 Marie-Elisabeth Bougnoux 43 Nathalie Kapel 44 Eric Dannaoui Alexis Valentin 45 Anne Totet 46 Jean Menotti 47 Denis Blanchet 48 Magalie Demar 48 Emmanuel Dutoit 16 Renaud Piarroux 49 Emilie Sitterlé 50 Denis Magne 51 Samsa Hamane 16 Antoine Berry 52 Cecile Ramade 16
Abstract : Cryptosporidiosis is a common disease in children and immunodeficient individuals. In 2006, a national network was set up on the surveillance of human cryptosporidiosis in France. Since January 2015, the 41 tertiary care hospitals and the 3 private laboratories of the French National Network on the surveillance of human cryptosporidiosis have been able to declare confirmed cases of cryptosporidiosis online. Between 2015 and 2017, 210 cases of cryptosporidiosis were declared in immunodeficient patients in France; Cryptosporidium parvum and Cryptosporidium hominis represented 66% and 22% of cases, respectively. A peak was observed in autumn. Cryptosporidiosis occurred mainly in a context of solid organ transplantation (SOT) (49%) and of HIV infection (30%). In SOT recipients, cryptosporidiosis appeared more frequently in the first 6 months post transplantation. Regarding cases declared in SOT recipients, mycophenolate mofetil was used in 68%. A mortality rate of 6% was observed. Present results underline the importance of screening for cryptosporidiosis in immunocompromised patients suffering from diarrhea, especially in the course of major cell mediated immunodeficiency or even systematic screening before SOT. Exclusive Cryptosporidium free water feeding could be suggested during major cell mediated immunodeficiency.
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https://hal.univ-lorraine.fr/hal-02902544
Contributor : Anne Debourgogne <>
Submitted on : Monday, July 20, 2020 - 9:32:46 AM
Last modification on : Monday, April 19, 2021 - 8:54:39 AM

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Damien Costa, Romy Razakandrainibe, Marc Sautour, Stéphane Valot, Louise Basmaciyan, et al.. Human cryptosporidiosis in immunodeficient patients in France (2015–2017). Experimental Parasitology, Elsevier, 2018, 192, pp.108-112. ⟨10.1016/j.exppara.2018.08.001⟩. ⟨hal-02902544⟩

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