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Multi-locus sequence typing provides epidemiological insights for diseased sharks infected with fungi belonging to the Fusarium solani species complex

Abstract : Fusarium spp. are saprobic moulds that are responsible for severe opportunistic infections in humans and animals. However, we need epidemiological tools to reliably trace the circulation of such fungal strains within medical or veterinary facilities, to recognize environmental contaminations that might lead to infection and to improve our understanding of factors responsible for the onset of outbreaks. In this study, we used molecular genotyping to investigate clustered cases of Fusarium solani species complex (FSSC) infection that occurred in eight Sphyrnidae sharks under managed care at a public aquarium. Genetic relationships between fungal strains were determined by multi-locus sequence typing (MLST) analysis based on DNA sequencing at five loci, followed by comparison with sequences of 50 epidemiologically unrelated FSSC strains. Our geno-typing approach revealed that F. keratoplasticum and F. solani haplotype 9x were most commonly isolated. In one case, the infection proved to be with another Hypocrealian rare opportunistic pathogen Metarhizium robertsii. Twice, sharks proved to be infected C The
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https://hal.univ-lorraine.fr/hal-02902565
Contributor : Anne Debourgogne <>
Submitted on : Monday, July 20, 2020 - 9:37:15 AM
Last modification on : Tuesday, October 13, 2020 - 10:46:19 AM

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Guillaume Desoubeaux, Anne Debourgogne, Nathan Wiederhold, Marie Zaffino, Deanna Sutton, et al.. Multi-locus sequence typing provides epidemiological insights for diseased sharks infected with fungi belonging to the Fusarium solani species complex. Medical Mycology, Oxford University Press, 2018, 56 (5), pp.591-601. ⟨10.1093/mmy/myx089⟩. ⟨hal-02902565⟩

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