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Editorial: Plant Glutathione Transferases: Diverse, Multi-Tasking Enzymes With Yet-to-Be Discovered Functions

Abstract : Plant genomes contain dozens of GSTs (Chi et al., 2011) encoding subunits that can form homodimers or heterodimers, leading to enormous diversity within GST protein families (Labrou et al., 2015). From its inception, plant GST research has successfully focused on investigating catalytic reactions with xenobiotic substrates (Cummins et al., 2011). By contrast, relatively few plant GST studies have successfully identified natural roles for this versatile multifunctional enzyme class, and despite few exceptions (Mueller et al., 2000; Bjarnholt et al., 2018), major breakthroughs have eluded researchers investigating their endogenous substrates and functions. With recent progress in molecular-genetics, physiology, and biochemistry, coupled with greatly increased sensitivity of mass spectrometry, it is timely to revisit potential candidates for natural GST substrates regarding catalysis, ligand binding, and transport roles, as well as summarize recent reports on xenobiotic detoxification and gene regulation mechanisms.
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https://hal.univ-lorraine.fr/hal-02988347
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Submitted on : Wednesday, November 4, 2020 - 4:52:09 PM
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Jolán Csiszár, Arnaud Hecker, Nikolaos Labrou, Peter Schröder, Dean Riechers. Editorial: Plant Glutathione Transferases: Diverse, Multi-Tasking Enzymes With Yet-to-Be Discovered Functions. Frontiers in Plant Science, Frontiers, 2019, 10 (50), pp.663-673. ⟨10.3389/fpls.2019.01304⟩. ⟨hal-02988347⟩

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