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Comparison of sTREM‐1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors

Abstract : Aim: The immune receptor triggering receptor expressed on myeloid cell-1 (TREM-1) is responsible for an amplification of the immuno-inflammatory response in inflam-matory diseases. Its role in the aetiopathogenesis of periodontitis is underexplored. The aim of this case-control and before-after study was to determine the evolution of soluble form of TREM-1 (sTREM-1) concentrations after scaling and root planing (SRP), and its prognostic value and evaluate associated microbial, periodontal and psychosocial factors. Methods: Gingival crevicular fluid was collected in two pathological sites (periodontal pocket depth (PPD) ≥ 5 mm) and one healthy site (PPD ≤ 3 mm) from thirty periodon-titis patients (before/after SRP), and in one healthy site from thirty controls (patients without periodontal disease). Each patient filled-in stress/anxiety self-assessment questionnaires and provided a saliva sample. Diseased patients were followed for a total of 13-15 weeks in initial periodontal treatment. sTREM-1 and salivary cortisol levels were determined by ELISA and periodontopathogens by PCR. Results: Before SRP, higher crevicular sTREM-1 levels were positively associated with some increased clinical parameters (Plaque Index, tooth mobility, bleeding on probing, p < .05) and inversely with Aggregatibacter actinomycetemcomitans abundance (p = .03). No correlation with psychological factors nor cortisol was found with salivary sTREM-1 concentrations. After SRP, crevicular sTREM-1 levels decreased (p < .001) and were not linked to a PPD decrease but remained higher in pathological than in healthy sites (p < .001). Higher concentrations were also found out in unim-proved sites (no change or increase in PPD) compared to improved ones (p = .02). Higher sTREM-1 levels were associated with Porphyromonas gingivalis, Treponema denticola and Campylobacter rectus in pathological sites after SRP (p < .05). Conclusion: Crevicular sTREM-1 level decreased after SRP but did not appear to be a site outcome predictive factor of periodontal healing and remained an inflammatory parameter.
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https://hal.univ-lorraine.fr/hal-02988707
Contributor : Catherine Bisson <>
Submitted on : Wednesday, February 10, 2021 - 11:41:34 AM
Last modification on : Thursday, February 11, 2021 - 3:28:24 AM

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Marie Dubar, Jean-Pol Frippiat, Thomas Rémen, Amir Boufenzer, Corentine Alauzet, et al.. Comparison of sTREM‐1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors. Journal of Clinical Periodontology, Wiley, 2020, 47, pp.1064 - 1078. ⟨10.1111/jcpe.13339⟩. ⟨hal-02988707⟩

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