Skip to Main content Skip to Navigation
Journal articles

Lipid composition of the cancer cell membrane

Abstract : Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition. Like in the case of phosphatidylcholine, these changes result in the modulation of certain enzymes and accumulation of energetic material, which could be used for a higher proliferation rate. The changes are so prominent, that some lipids, such as phosphatidylserines, could even be considered as the cancer biomarkers. Additionally, some changes of biophysical properties of cell membranes lead to the higher resistance to chemotherapy, and finally to the disturbances in signalling pathways. Namely, the increased levels of certain lipids, like for instance phosphatidylserine, lead to the attenuation of the immune system response. Also, changes in lipid saturation prevent the cells from demanding conditions of the microenvironment. Particularly interesting is the significance of cell membrane cholesterol content in the modulation of metastasis. This review paper discusses the roles of each lipid type in cancer physiology. The review combined theoretical data with clinical studies to show novel therapeutic options concerning the modulation of cell membranes in oncology.
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03089978
Contributor : Mounir Tarek Connect in order to contact the contributor
Submitted on : Tuesday, December 29, 2020 - 8:42:29 AM
Last modification on : Tuesday, January 5, 2021 - 3:27:30 AM
Long-term archiving on: : Tuesday, March 30, 2021 - 6:07:10 PM

File

Szlasa2020_Article_LipidCompos...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Wojciech Szlasa, Iga Zendran, Aleksandra Zalesińska, Mounir Tarek, Julita Kulbacka. Lipid composition of the cancer cell membrane. Journal of Bioenergetics and Biomembranes, Springer Verlag, 2020, 52 (5), pp.321-342. ⟨10.1007/s10863-020-09846-4⟩. ⟨hal-03089978⟩

Share

Metrics

Record views

52

Files downloads

316