Contacts between titanium alloys may use an anti-fretting coating on one component. However violent events may cause severe sliding.In the high speed and pressure (up to 60 m/s and 280 MPa) sliding of a non-coated on a coated part, we investigate the influence of the coating (CoCrAlYSiBN or CuNiIn) on the friction coefficient, wear, and microstructural affectations. Both coatings did not significantly influence the friction coefficient but reduced the wear.A scenario based on interface-localized heat explaining the generation of a third body and its influence on the tribological behavior was proposed. The dependence of the mechanical and thermal affectations on the coating material was explained based on the kinetic of the α→β phase transformation of the Ti6Al4V alloy.