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Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs

Abstract : Box C/D small nucleolar RNAs (C/D snoRNAs) represent an ancient family of small non-coding RNAs that are classically viewed as housekeeping guides for the 2′-O-methylation of ribosomal RNA in Archaea and Eukaryotes. However, an extensive set of studies now argues that they are involved in mechanisms that go well beyond this function. Here, we present these pieces of evidence in light of the current comprehension of the molecular mechanisms that control C/D snoRNA expression and function. From this inventory emerges that an accurate description of these activities at a molecular level is required to let the snoRNA field enter in a second age of maturity.
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https://hal.univ-lorraine.fr/hal-03222458
Contributor : Bruno Charpentier <>
Submitted on : Monday, May 10, 2021 - 11:45:53 AM
Last modification on : Tuesday, May 11, 2021 - 3:35:56 AM

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Laeya Baldini, Bruno Charpentier, Stéphane Labialle. Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs. Non-Coding RNA, MDPI, 2021, 7 (2), pp.30. ⟨10.3390/ncrna7020030⟩. ⟨hal-03222458⟩

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