Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion

Mohammad Anadani; Gaultier Marnat; Arturo Consoli; Panagiotis Papanagiotou; Raul Nogueira; Alejandro Spiotta; Romain Bourcier; Maeva Kyheng; Julien Labreuche; Adnan Siddiqui; Marc Ribo; Adam de Havenon; Urs Fischer; Igor Sibon; Cyril Dargazanli; Caroline Arquizan; Christophe Cognard; Jean Marc Olivot; René Anxionnat; Gérard Audibert; Mikael Mazighi; Raphaël Blanc; Bertrand Lapergue; Sébastien Richard; Benjamin Gory; Francis Turjman; Michel Piotin; Henrik Steglich-Arnholm; Markus Holtmannspötter; Christian Taschner; Sebastian Eiden; Diogo C. Haussen; Waqas Muhammad; Maria Boutchakova; Franziska Dorn; Monika Killer-Oberpfalzer; Salvatore Mangiafico; Marios-Nikos Psychogios; Marc-Antoine Labeyrie; Alessandra Biondi; Serge Bracard; Jonathan Andrew Grossberg; Adrien Guenego; Julien Darcourt; Isabelle Vukasinovic; Elisa Pomero; Jason Davies; Leonardo Renieri; Corentin Hecker; Maria Muchada Muchada; Georges Rodesch; Emmanuel Houdart; Johanna Lockau; Andreas Kastrup; Hocine Redjem; Daniel Behme; Hussain Shallwani; Maurer Christopher; Gioia Mione; Lisa Humbertjean; Nolwenn Riou-Comte; François Zhu; Anne-Laure Borderelle; Liang Liao; Simon Escalard; Jean-Philippes Desilles; Gabriele Ciccio; Stanislas Smajda; Mikael Obadia; Candice Sabben; Ovide Corabianu; Thomas de Broucker; Didier Smadja; Sonia Alamowitch; Olivier Ille; Éric Manchon; Pierre-Yves Garcia; Guillaume Taylor; Malek Ben Maacha; Adrien Wang; Serge Evrard; Maya Tchikviladze; Nadia Ajili; David Weisenburger; Lucas Gorza; Oguzhan Coskun; Federico Di Maria; Georges Rodesh; Morgan Leguen; Julie Gratieux; Fernando Pico; Haja Rakotoharinandrasana; Philippe Tassan; Roxanna Poll; Sylvie Marinier; Florent Gariel; Xavier Barreau; Jérôme Berge; Louis Veunac; Patrice Menegon; Ludovic Lucas; Stéphane Olindo; Pauline Renou; Sharmila Sagnier; Mathilde Poli; Sabrina Debruxelles; Thomas Tourdias; Jean-Sébastien Liegey; Benjamin Daumas-Duport; Pierre-Louis Alexandre; Monica Roy; Cédric Lenoble; Vincent L'Allinec; Jean-Baptiste Girot; Hubert Desal; Marc Braun; Anne-Laure Derelle; Romain Tonnelet; Emmanuelle Schmitt; Sophie Planel; Jean-Christophe Lacour; Gabriela Hossu; Marine Beaumont; Mitchelle Bailang; Marie Reitter; Agnès Masson; Lionel Alb; Adriana Tabarna; Marcela Voicu; Iona Podar; Madalina Brezeanu; Vincent Costalat; Gregory Gascou; Pierre-Henri Lefevre; Imad Derraz; Carlos Riquelme; Nicolas Gaillard; Isabelle Mourand; Lucas Corti

doi:10.1136/neurintsurg-2020-017202

Journal Articles Journal of Neurointerventional Surgery Year : 2021

Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion

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Mohammad Anadani

Function : Author
PersonId : 801468
ORCID : 0000-0002-7813-2949

Washington University School of Medicine in St. Louis

Medical University of South Carolina [Charleston]

Gaultier Marnat

Function : Author
PersonId : 1036360

Département de Neuro-Radiologie [Bordeaux]

Arturo Consoli

Function : Author
PersonId : 786640
ORCID : 0000-0001-6640-8541

Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch]

Panagiotis Papanagiotou

Function : Author

National and Kapodistrian University of Athens

Raul Nogueira

Function : Author

Emory University School of Medicine

Alejandro Spiotta

Function : Author

Medical University of South Carolina [Charleston]

Romain Bourcier

Function : Author
PersonId : 1083601

Nantes Université - pôle Santé

Maeva Kyheng

Function : Author
PersonId : 1260234
ORCID : 0000-0002-8915-0915
IdRef : 250816040

Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Julien Labreuche

Function : Author

Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Adnan Siddiqui

Function : Author

University at Buffalo [SUNY]

Marc Ribo

Function : Author
PersonId : 757305
ORCID : 0000-0001-9242-043X

Vall d'Hebron University Hospital [Barcelona]

Adam de Havenon

Function : Author
PersonId : 807050
ORCID : 0000-0001-8178-8597

University of Utah

Urs Fischer

Function : Author
PersonId : 770350
ORCID : 0000-0003-0521-4051

Inselspital Bern

Igor Sibon

Function : Author
PersonId : 1122973

Service de neurologie [Bordeaux]

Cyril Dargazanli

Function : Author
PersonId : 1069427

Neuroradiologie [Hôpital Gui de Chauliac]

Caroline Arquizan

Function : Author
PersonId : 1069436

Neurochirurgie [Hôpital Gui de Chauliac]

Christophe Cognard

Function : Author

Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse]

Jean Marc Olivot

Function : Author
PersonId : 1199283
ORCID : 0000-0003-2027-2276
IdRef : 109426452

Centre Hospitalier Universitaire de Toulouse

Département de Neurologie [Toulouse]

René Anxionnat

Function : Author

Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy]

Imagerie Adaptative Diagnostique et Interventionnelle

Gérard Audibert

Function : Author
PersonId : 918705

Centre Hospitalier Régional Universitaire de Nancy

Mikael Mazighi

Function : Author
PersonId : 1104545

CHU Rothschild [AP-HP]

Raphaël Blanc

Function : Author

CHU Rothschild [AP-HP]

Bertrand Lapergue

Function : Author
PersonId : 1089358

Hôpital Foch [Suresnes]

UFR Sciences de la santé Simone Veil

Sébastien Richard

Function : Author
PersonId : 845623

Service de neurologie [CHRU Nancy]

Benjamin Gory

Function : Author
PersonId : 762859
ORCID : 0000-0001-8424-4464

Imagerie Adaptative Diagnostique et Interventionnelle

Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy]

Francis Turjman

Function : Author

Michel Piotin

Function : Author
PersonId : 767048
ORCID : 0000-0002-1354-4328
IdRef : 104505605

Henrik Steglich-Arnholm

Function : Author

Markus Holtmannspötter

Function : Author

Christian Taschner

Function : Author

Sebastian Eiden

Function : Author

Diogo C. Haussen

Function : Author

Waqas Muhammad

Function : Author

Maria Boutchakova

Function : Author

Franziska Dorn

Function : Author

Monika Killer-Oberpfalzer

Function : Author
PersonId : 801469
ORCID : 0000-0001-5572-7694

Salvatore Mangiafico

Function : Author

Marios-Nikos Psychogios

Function : Author

Marc-Antoine Labeyrie

Function : Author

Alessandra Biondi

Function : Author

Serge Bracard

Function : Author
PersonId : 1033868

Jonathan Andrew Grossberg

Function : Author

Adrien Guenego

Function : Author

Julien Darcourt

Function : Author

Isabelle Vukasinovic

Function : Author

Elisa Pomero

Function : Author

Jason Davies

Function : Author

Leonardo Renieri

Function : Author

Corentin Hecker

Function : Author

Maria Muchada Muchada

Function : Author

Georges Rodesch

Function : Author

Emmanuel Houdart

Function : Author

Johanna Lockau

Function : Author

Andreas Kastrup

Function : Author

Hocine Redjem

Function : Author
PersonId : 779240
ORCID : 0000-0002-6943-9922

Daniel Behme

Function : Author

Hussain Shallwani

Function : Author

Maurer Christopher

Function : Author

Gioia Mione

Function : Author

Lisa Humbertjean

Function : Author

Nolwenn Riou-Comte

Function : Author

François Zhu

Function : Author
PersonId : 1376787
IdHAL : francois-zhu

Anne-Laure Borderelle

Function : Author

Liang Liao

Function : Author
PersonId : 1109853

Simon Escalard

Function : Author
PersonId : 798860
ORCID : 0000-0003-1306-1008

Jean-Philippes Desilles

Function : Author

Gabriele Ciccio

Function : Author
PersonId : 786642
ORCID : 0000-0001-5801-0816

Stanislas Smajda

Function : Author

Mikael Obadia

Function : Author

Candice Sabben

Function : Author

Ovide Corabianu

Function : Author

Thomas de Broucker

Function : Author

Didier Smadja

Function : Author

Sonia Alamowitch

Function : Author

Olivier Ille

Function : Author

Éric Manchon

Function : Author

Pierre-Yves Garcia

Function : Author

Guillaume Taylor

Function : Author

Malek Ben Maacha

Function : Author

Adrien Wang

Function : Author

Serge Evrard

Function : Author
PersonId : 906555

Maya Tchikviladze

Function : Author

Nadia Ajili

Function : Author

David Weisenburger

Function : Author

Lucas Gorza

Function : Author

Oguzhan Coskun

Function : Author

Federico Di Maria

Function : Author
PersonId : 1089947

Georges Rodesh

Function : Author

Morgan Leguen

Function : Author

Julie Gratieux

Function : Author

Fernando Pico

Function : Author
PersonId : 1037856
ORCID : 0000-0002-3329-5365

Haja Rakotoharinandrasana

Function : Author

Philippe Tassan

Function : Author

Roxanna Poll

Function : Author

Sylvie Marinier

Function : Author

Florent Gariel

Function : Author
PersonId : 791792
ORCID : 0000-0003-4636-2034

Xavier Barreau

Function : Author

Jérôme Berge

Function : Author

Louis Veunac

Function : Author

Patrice Menegon

Function : Author

Ludovic Lucas

Function : Author

Stéphane Olindo

Function : Author

Pauline Renou

Function : Author

Sharmila Sagnier

Function : Author

Mathilde Poli

Function : Author

Sabrina Debruxelles

Function : Author

Thomas Tourdias

Function : Author
PersonId : 914201

Jean-Sébastien Liegey

Function : Author

Benjamin Daumas-Duport

Function : Author

Pierre-Louis Alexandre

Function : Author

Monica Roy

Function : Author

Cédric Lenoble

Function : Author

Vincent L'Allinec

Function : Author

Jean-Baptiste Girot

Function : Author
PersonId : 807041
ORCID : 0000-0002-2780-6907

Hubert Desal

Function : Author
PersonId : 1032788

Marc Braun

Function : Author

Anne-Laure Derelle

Function : Author

Romain Tonnelet

Function : Author
PersonId : 1104588

Emmanuelle Schmitt

Function : Author
PersonId : 1041192

Sophie Planel

Function : Author

Jean-Christophe Lacour

Function : Author

Gabriela Hossu

Function : Author
PersonId : 746470
IdHAL : gabriela-hossu
ORCID : 0000-0003-1178-9097
IdRef : 140763341

Marine Beaumont

Function : Author
PersonId : 746471
IdHAL : marine-beaumont
ORCID : 0000-0002-3269-5447
IdRef : 126605092

Mitchelle Bailang

Function : Author

Marie Reitter

Function : Author

Agnès Masson

Function : Author

Lionel Alb

Function : Author

Adriana Tabarna

Function : Author

Marcela Voicu

Function : Author

Iona Podar

Function : Author

Madalina Brezeanu

Function : Author

Vincent Costalat

Function : Author
PersonId : 1056305

Centre Hospitalier Régional Universitaire [Montpellier]

Institut de Génomique Fonctionnelle

Gregory Gascou

Function : Author
PersonId : 999984

Pierre-Henri Lefevre

Function : Author
PersonId : 1133094

Imad Derraz

Function : Author
PersonId : 1094364

Carlos Riquelme

Function : Author
PersonId : 765337
ORCID : 0000-0001-6352-7713

Nicolas Gaillard

Function : Author
PersonId : 1069430

Isabelle Mourand

Function : Author
PersonId : 1069425

Lucas Corti

Function : Author
PersonId : 1069432

Abstract

Background Endovascular therapy (EVT) is effective and safe in patients with tandem occlusion. The benefit of intravenous thrombolysis (IVT) prior to EVT in acute tandem occlusion is debatable. Objective To compare EVT alone with EVT plus IVT in patients with acute ischemic stroke due to anterior circulation tandem occlusions. Methods This is an individual patient pooled analysis of the Thrombectomy In TANdem lesions (TITAN) and Endovascular Treatment in Ischemic Stroke (ETIS) Registries. Patients were divided into two groups based on prior IVT treatment: (1) IVT+ group, which included patients who received IVT prior to EVT, (2) IVT− group, which included patients who did not receive IVT prior to EVT. Propensity score (inverse probability of treatment weighting (IPTW)) was used to reduce baseline between-group differences. The primary outcome was favorable outcome—that is, modified Rankin Scale (mRS) score 0 to 2 at 90 days. Results Overall, 602 consecutive patients with an acute stroke with tandem occlusion were included (380 and 222 in the bridging therapy and EVT alone groups, respectively). Onset to imaging time was shorter in the IVT+ group (median 103 vs 140 min). In contrast, imaging to puncture time was longer in the IVT+ group (median 107 vs 91 min). In IPTW analysis, the IVT+ group had higher odds of favorable outcome, excellent outcome (90-day mRS score 0–1), and successful reperfusion (modified Thrombolysis in Cerebral Infarction score 2b/3 at the end of EVT). There was no difference in the risk of significant hemorrhagic complications between groups. In secondary analysis of patients treated with acute cervical internal carotid artery stenting, bridging therapy was associated with higher odds of favorable outcome and lower odds of mortality at 90 days. Conclusions Our results suggest that bridging therapy in patients with acute ischemic stroke due to anterior tandem occlusion is safe and may improve functional outcome, even in the setting of acute cervical internal carotid artery stenting during EVT.

Keywords

Hemorrhage Stroke Thrombectomy

Domains

Medical Imaging Nuclear medicine Human health and pathology Surgery Neurons and Cognition [q-bio.NC]

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https://hal.univ-lorraine.fr/hal-03224258

Submitted on : Tuesday, May 11, 2021-3:09:40 PM

Last modification on : Monday, November 18, 2024-4:21:56 PM

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hal-03224258 , version 1 (11-05-2021)

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HAL Id : hal-03224258 , version 1
DOI : 10.1136/neurintsurg-2020-017202
PUBMED : 33911016
WOS : 000728746700001

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Mohammad Anadani, Gaultier Marnat, Arturo Consoli, Panagiotis Papanagiotou, Raul Nogueira, et al.. Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion. Journal of Neurointerventional Surgery, inPress, 52 (10), pp.3097-3105. ⟨10.1136/neurintsurg-2020-017202⟩. ⟨hal-03224258⟩

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Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion

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