Skip to Main content Skip to Navigation
Journal articles

Contrast-enhanced 3T MR Perfusion of Musculoskeletal Tumours: T1 Value Heterogeneity Assessment and Evaluation of the Influence of T1 Estimation Methods on Quantitative Parameters

Abstract : Objective: To evaluate intra-tumour and striated muscle T1 value heterogeneity and the influence of different methods of T1 estimation on the variability of quantitative perfusion parameters. Material and methods: Eighty-two patients with a histologically confirmed musculoskeletal tumour were prospectively included in this study and, with ethics committee approval, underwent contrast-enhanced MR perfusion and T1 mapping. T1 value variations in viable tumour areas and in normal-appearing striated muscle were assessed. In 20 cases, normal muscle perfusion parameters were calculated using three different methods: signal based and gadolinium concentration based on fixed and variable T1 values. Results: Tumour and normal muscle T1 values were significantly different (p = 0.0008). T1 value heterogeneity was higher in tumours than in normal muscle (variation of 19.8% versus 13%). The T1 estimation method had a considerable influence on the variability of perfusion parameters. Fixed T1 values yielded higher coefficients of variation than variable T1 values (mean 109.6 ± 41.8% and 58.3 ± 14.1% respectively). Area under the curve was the least variable parameter (36%). Conclusion: T1 values in musculoskeletal tumours are significantly different and more heterogeneous than normal muscle. Patient-specific T1 estimation is needed for direct inter-patient comparison of perfusion parameters. Key points: • T1 value variation in musculoskeletal tumours is considerable. • T1 values in muscle and tumours are significantly different. • Patient-specific T1 estimation is needed for comparison of inter-patient perfusion parameters. • Technical variation is higher in permeability than semiquantitative perfusion parameters.
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03241205
Contributor : Juliette Birker Connect in order to contact the contributor
Submitted on : Friday, May 28, 2021 - 2:53:56 PM
Last modification on : Thursday, November 18, 2021 - 4:56:08 PM

Identifiers

Collections

Citation

Pedro Augusto Gondim Teixeira, Christophe Leplat, Bailiang Chen, Jacques de Verbizier, Marine Beaumont, et al.. Contrast-enhanced 3T MR Perfusion of Musculoskeletal Tumours: T1 Value Heterogeneity Assessment and Evaluation of the Influence of T1 Estimation Methods on Quantitative Parameters. European Radiology, Springer Verlag, 2017, 27 (12), pp.4903-4912. ⟨10.1007/s00330-017-4891-z⟩. ⟨hal-03241205⟩

Share

Metrics

Record views

19