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Epidemiology of heart failure and long-term follow-up outcomes in a north-African population: Results from the NAtional TUnisian REgistry of Heart Failure (NATURE-HF)

Leila Abid 1 Salma Charfeddine 2 Ikram Kammoun 3 Manel Ben Halima 4 Hedi Ben Slima 5 Meriem Drissa 4 Khadija Mzoughi 6 Dorra Mbarek 7 Leila Riahi 1 Saoussen Antit 8 Afef Ben Halima 3 Wejdene Ouechtati 9 Emna Allouche 9 Mehdi Mechri 4 Chedi Youssfi 2 Ali Khorchani 10 Kais Sammoud 4 Khaled Zaouia 10 Rami Tlili 7 Sana Ouali 4 Faten Triki 2 Sonia Hamdi 11 Selim Boudich 4 Marwa Chebbi 4 Mouna Hentati 12 Amani Farah 13 Habib Triki 14 H. Ghardallou 15 H. Radoui 16 Sofien Zayed 13 F. Azaiez 4 Fadoua Omri 5 Akram Zouari 2 Zine Ben Ali 2 A. Najjar 13 Houssem Thabet 15 Mouna Chaker 2 Samar Mohammed 8 Abdelhamid Ben Jmaa 2 Haithem Tangour 15 Yassine Kammoun 17 Mahmoud Cheikh Bouhlel 15 S. Azeiz 1 R. Gtaief 1 S. Mashki 1 Aymen Amri 1 Hela Naanea 1 Raoudha Othmani 1 Iheb Chahbani 1 Houcine Zargouni 1 Syrine Abid 1 Mokded Ayari 1 Ines Ben Ameur 1 Ali Guesmi 18 Nejeh Ben Halima 19 Habib Haouala 11 Wafa Fehri 11 Essia Boughzela 15 Lilia Zakhama 8 Soraya Ben Youssef 8 Wided Nasraoui 20 Rachid Boujneh 7 Nedia Barakett 21 Sondos Kraiem 6 Hbiba Drissa 4 Ali Ben Khalfalah 22 Habib Gamra 13 Salem Kachboura 16 Yosra Majdoub 2 Elifa Kanoun 23 Faiez Zannad 24, 25, 26, 27 Sami Milouchi 10 Alexandre Mebaza 28 Samir Kammoun 2 Sami Mourali 4 Karima Hezbri 29 Faouzi Addad 16 
Abstract : The NATURE-HF registry was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). This is a prospective, multicenter, observational survey conducted in Tunisian Cardiology centers. A total of 2040 patients were included in the study. Of these, 1632 (80%) were outpatients with chronic HF (CHF). The mean hospital stay was 8.7 ± 8.2 days. The mortality rate during the initial hospitalization event for AHF was 7.4%. The all-cause 1-year mortality rate was 22.8% among AHF patients and 10.6% among CHF patients. Among CHF patients, the older age, diabetes, anemia, reduced EF, ischemic etiology, residual congestion and the absence of ACEI/ ARBs treatment were independent predictors of 1-year cumulative rates of rehospitalization and mortality. The female sex and the functional status were independent predictors of 1-year all-cause mortality and rehospitalization in AHF patients. This study confirmed that acute HF is still associated with a poor prognosis, while the mid-term outcomes in patients with chronic HF seems to be improved. Some differences across countries may be due to different clinical characteristics and differences in healthcare systems.
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Submitted on : Friday, June 11, 2021 - 3:26:52 PM
Last modification on : Saturday, August 21, 2021 - 3:04:33 AM
Long-term archiving on: : Sunday, September 12, 2021 - 7:58:47 PM




Leila Abid, Salma Charfeddine, Ikram Kammoun, Manel Ben Halima, Hedi Ben Slima, et al.. Epidemiology of heart failure and long-term follow-up outcomes in a north-African population: Results from the NAtional TUnisian REgistry of Heart Failure (NATURE-HF). PLoS ONE, Public Library of Science, 2021, 16 (5), pp.e0251658. ⟨10.1371/journal.pone.0251658⟩. ⟨hal-03258487⟩



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