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Impact d’une réduction d’activité sur la mesure de la fraction d’éjection du ventricule gauche sur caméra D-SPECT

Abstract : Introduction Radionuclide ventriculography provides a reproducible measurement of the left ventricular fraction ejection (LVEF) but with a significant body radiation (effective dose of 5,9 mSv for the injection of 850 Mbq of 99mTc). The highly sensitive semi-conductor (CZT) cameras could allow decreasing the injected activity by a factor 3, similarly to that of myocardial perfusion imaging. Our study was aimed to determine whether the LVEF measurement provided by radionuclide ventriculography on the CZT D-SPECT camera is impacted by a 70% reduction in recorded counts. Materials and methods After the in vivo labeling of red blood cells with 850 MBq of 99mTc, 49 patients completed a conventional 2D recording (Conv-2D) on Anger camera followed by a 3D recording on the D-SPECT camera (3D-100%). The CZT recordings of all projections were subsequently shortened to 30% of their initial durations (3D-30%) in order to assess the LVEF measured with a 70% reduction in recorded counts. Results Mean LVEF values were 62.7 ± 11.1% on Conv-2D and higher on both 3D-100% (66.8 ± 14.8%, P < 0.001) and 3D-30% (66.3 ± 15.7%, P < 0.001). The correlation coefficients with the LVEF determined with the reference Conv-2D method were equivalents for 3D-100% (r2 = 0.73) and 3D-30% (r2 = 0.70) and with a similar level of overestimation for the highest LEVF values. Conclusion A 70% reduction in recorded counts does not significantly impact the LVEF measured with radionuclide ventriculography on the CZT D-SPECT camera. These values are coherent with those obtained with the reference 2D method but with a clear overestimation for the highest LVEF values.
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https://hal.univ-lorraine.fr/hal-03259689
Contributor : Juliette Birker <>
Submitted on : Monday, June 14, 2021 - 2:01:32 PM
Last modification on : Wednesday, June 23, 2021 - 12:52:21 PM

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H. Tissot, O. Morel, L. Imbert, V. Roch, M. Claudin, et al.. Impact d’une réduction d’activité sur la mesure de la fraction d’éjection du ventricule gauche sur caméra D-SPECT. Médecine Nucléaire, Elsevier/Masson, 2017, 41 (2), pp.83-92. ⟨10.1016/j.mednuc.2017.02.008⟩. ⟨hal-03259689⟩

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