Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study - Université de Lorraine Access content directly
Journal Articles Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Year : 2018

Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Mathieu Ceccaldi (1, 2) , Thérèse Jonveaux (3) , Antoine Verger (4) , Pierre Krolak-Salmon (5) , Claire Houzard (6) , Olivier Godefroy (7, 8) , Trevor Shields (9) , Audrey Perrotin (10) , Rossella Gismondi (10) , Santiago Bullich (11) , Aleksandar Jovalekic (12) , Nicola Raffa (2) , Florence Pasquier (2) , Franck Semah (2) , Bruno Dubois (2) , Marie-Odile Habert (2) , David Wallon (13, 14) , Mathieu Chastan (15) , Pierre Payoux (16) , Olivier Felician (2) , Mira Didic (2) , Claude Gueriot , Lejla Koric , Radka Kletchkova-Gantchev , Daniela Andriuta (7) , Agnès Devendeville , Diane Dupuis , Ingrid Binot , Mélanie Barbay (7) , Marc-Etienne Meyer , Véronique Moullard , Eloi Magnin , Ludivine Chamard , Sophie Haffen , Clément Drouet , Hatem Boulahdour , Philippe Goas , Solène Querellou-Lefranc , Vincent de La Sayette , Julien Cogez , Pierre Branger , Denis Agostini , Alain Manrique , Yannick Bejot , Agnès Jacquin-Piques , Inna Dygai-Cochet , Alina Berriolo-Riedinger , Olivier Moreaud , Mathilde Sauvee , Céline Gallazzani Crépin , Stéphanie Bombois , Thibaud Lebouvier , Marie-Anne Mackowiak-Cordoliani , Vincent Deramecourt , Adeline Rollin-Sillaire , Pascaline Cassagnaud-Thuillet , Yaohua Chen , Grégory Petyt , Denis Federico , Keren Liora Danaila , Yves Guilhermet , Christophe Magnier , Zaza Makaroff , Isabelle Rouch , Jing Xie , Caroline Roubaud , Marie-Hélène Coste , Kenny David , Alain Sarciron , Aziza Sediq Waissi , Christian Scheiber , Audrey Gabelle-Deloustal , Karim Bennys , Cecilia Marelli , Lynda Touati , Delphine de Verbizier-Lonjon , Athanase Benetos , Anna Kearney-Schwartz , Christine Perret-Guillaume , Martine Vercelletto , Claire Boutoleau-Bretonniere , Hélène Pouclet-Courtemanche , Nathalie Wagemann , Amandine Pallardy , Jacques Hugon , Claire Paquet , Julien Dumurgier , Pascal Millet , Mathieu Queneau , Stéphane Epelbaum , Marcel Levy , Jean-Luc Novella , Yacine Jaidi , David Morland , Serge Belliard , Anne Salmon , Florence Lejeune , Didier Hannequin , Olivier Martinaud , Aline Zarea , Jérémie Pariente , Claire Thalamas , Monique Galitzky-Gerber , Anne-Marie Tricoire Ricard , Fabienne Calvas , Emilie Rigal , Anne Hitzel , Julien Delrieu , Pierre-Jean Ousset , Françoise Lala , Nathalie Sastre-Hengan , Olivier Morel (17) , Olivier Rouaud , Denis Mariano-Goulart (18) , Dimitri Papathanassiou (19) , Florence Le Jeune (20) , Andrew Stephens (2) , Eric Guedj (2)
Audrey Perrotin
  • Function : Author
Pierre Payoux
Mira Didic
Claude Gueriot
  • Function : Author
Lejla Koric
  • Function : Author
Radka Kletchkova-Gantchev
  • Function : Author
Agnès Devendeville
  • Function : Author
Diane Dupuis
  • Function : Author
Ingrid Binot
  • Function : Author
Marc-Etienne Meyer
Véronique Moullard
  • Function : Author
Eloi Magnin
Ludivine Chamard
  • Function : Author
Sophie Haffen
  • Function : Author
Clément Drouet
  • Function : Author
Hatem Boulahdour
  • Function : Author
Philippe Goas
  • Function : Author
Solène Querellou-Lefranc
  • Function : Author
Vincent de La Sayette
  • Function : Author
Julien Cogez
  • Function : Author
Pierre Branger
  • Function : Author
Denis Agostini
  • Function : Author
Alain Manrique
  • Function : Author
Yannick Bejot
Agnès Jacquin-Piques
  • Function : Author
Inna Dygai-Cochet
  • Function : Author
Alina Berriolo-Riedinger
  • Function : Author
Olivier Moreaud
  • Function : Author
Mathilde Sauvee
  • Function : Author
Céline Gallazzani Crépin
  • Function : Author
Stéphanie Bombois
  • Function : Author
Thibaud Lebouvier
  • Function : Author
Vincent Deramecourt
  • Function : Author
Adeline Rollin-Sillaire
  • Function : Author
Pascaline Cassagnaud-Thuillet
  • Function : Author
Yaohua Chen
  • Function : Author
Grégory Petyt
  • Function : Author
Denis Federico
  • Function : Author
Keren Liora Danaila
  • Function : Author
Yves Guilhermet
  • Function : Author
Christophe Magnier
  • Function : Author
Zaza Makaroff
  • Function : Author
Isabelle Rouch
  • Function : Author
Jing Xie
  • Function : Author
  • PersonId : 760658
  • IdRef : 185440193
Caroline Roubaud
  • Function : Author
Marie-Hélène Coste
  • Function : Author
Kenny David
  • Function : Author
Alain Sarciron
  • Function : Author
Aziza Sediq Waissi
  • Function : Author
Christian Scheiber
  • Function : Author
Audrey Gabelle-Deloustal
  • Function : Author
Karim Bennys
  • Function : Author
Cecilia Marelli
  • Function : Author
Lynda Touati
  • Function : Author
Delphine de Verbizier-Lonjon
  • Function : Author
Athanase Benetos
Anna Kearney-Schwartz
  • Function : Author
  • PersonId : 764739
  • IdRef : 075209756
Christine Perret-Guillaume
  • Function : Author
  • PersonId : 764738
  • IdRef : 095285318
Martine Vercelletto
  • Function : Author
Claire Boutoleau-Bretonniere
  • Function : Author
Hélène Pouclet-Courtemanche
  • Function : Author
Nathalie Wagemann
  • Function : Author
Amandine Pallardy
  • Function : Author
Jacques Hugon
  • Function : Author
Claire Paquet
  • Function : Author
Julien Dumurgier
Pascal Millet
  • Function : Author
Mathieu Queneau
  • Function : Author
Stéphane Epelbaum
  • Function : Author
Marcel Levy
  • Function : Author
Jean-Luc Novella
Yacine Jaidi
  • Function : Author
David Morland
  • Function : Author
Serge Belliard
  • Function : Author
Anne Salmon
  • Function : Author
Florence Lejeune
  • Function : Author
Didier Hannequin
  • Function : Author
Olivier Martinaud
  • Function : Author
Aline Zarea
  • Function : Author
Jérémie Pariente
  • Function : Author
Claire Thalamas
  • Function : Author
Monique Galitzky-Gerber
  • Function : Author
Anne-Marie Tricoire Ricard
  • Function : Author
Fabienne Calvas
  • Function : Author
Emilie Rigal
  • Function : Author
Anne Hitzel
  • Function : Author
Julien Delrieu
  • Function : Author
Pierre-Jean Ousset
  • Function : Author
Françoise Lala
  • Function : Author
Nathalie Sastre-Hengan
  • Function : Author
Olivier Rouaud
  • Function : Author
Eric Guedj

Abstract

IntroductionAlthough some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting.MethodsThis multicenter study was performed at French tertiary memory clinics in patients presenting with most complex clinical situations (i.e., early-onset, atypical clinical profiles, suspected mixed etiological conditions, unexpected rate of progression), for whom cerebrospinal fluid analysis was indicated but either not feasible or considered as noncontributory (ClinicalTrials.gov: NCT02681172).ResultsTwo hundred five patients were enrolled with evaluable florbetaben PET scans; 64.4% of scans were amyloid positive. PET results led to changed diagnosis and improved confidence in 66.8% and 81.5% of patients, respectively, and altered management in 80.0% of cases.DiscussionHigh-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases.
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hal-03266901 , version 1 (22-06-2021)

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Attribution - NonCommercial - NoDerivatives

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Mathieu Ceccaldi, Thérèse Jonveaux, Antoine Verger, Pierre Krolak-Salmon, Claire Houzard, et al.. Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018, 14 (3), pp.293-305. ⟨10.1016/j.jalz.2017.09.009⟩. ⟨hal-03266901⟩
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