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Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Mathieu Ceccaldi 1, 2, * Thérèse Jonveaux 3 Antoine Verger 4 Pierre Krolak-Salmon 5 Claire Houzard 6 Olivier Godefroy 7 Trevor Shields 8 Audrey Perrotin 9 Rossella Gismondi 9 Santiago Bullich 10 Aleksandar Jovalekic 11 Nicola Raffa 2 Florence Pasquier 2 Franck Semah 2 Bruno Dubois 2 Marie-Odile Habert 2 David Wallon 12, 13 Mathieu Chastan 14 Pierre Payoux 15 Olivier Felician 2 Mira Didic 2 Claude Gueriot Lejla Koric Radka Kletchkova-Gantchev Daniela Andriuta Agnès Devendeville Diane Dupuis Ingrid Binot Mélanie Barbay Marc-Etienne Meyer Véronique Moullard Eloi Magnin Ludivine Chamard Sophie Haffen Clément Drouet Hatem Boulahdour Philippe Goas Solène Querellou-Lefranc Vincent de la Sayette Julien Cogez Pierre Branger Denis Agostini Alain Manrique Yannick Bejot Agnès Jacquin-Piques Inna Dygai-Cochet Alina Berriolo-Riedinger Olivier Moreaud Mathilde Sauvee Céline Crépin Stéphanie Bombois Thibaud Lebouvier Marie-Anne Mackowiak-Cordoliani Vincent Deramecourt Adeline Rollin-Sillaire Pascaline Cassagnaud-Thuillet Yaohua Chen Grégory Petyt Denis Federico Keren Danaila Yves Guilhermet Christophe Magnier Zaza Makaroff Isabelle Rouch Jing Xie Caroline Roubaud Marie-Hélène Coste Kenny David Alain Sarciron Aziza Waissi Christian Scheiber Audrey Gabelle-Deloustal Karim Bennys Cecilia Marelli Lynda Touati Delphine de Verbizier-Lonjon Athanase Benetos Anna Kearney-Schwartz Christine Perret-Guillaume Martine Vercelletto Claire Boutoleau-Bretonniere Hélène Pouclet-Courtemanche Nathalie Wagemann Amandine Pallardy Jacques Hugon Claire Paquet Julien Dumurgier Pascal Millet Mathieu Queneau Stéphane Epelbaum Marcel Levy Jean-Luc Novella Yacine Jaidi David Morland Serge Belliard Anne Salmon Florence Lejeune Didier Hannequin Olivier Martinaud Aline Zarea Jérémie Pariente Claire Thalamas Monique Galitzky-Gerber Anne-Marie Tricoire Ricard Fabienne Calvas Emilie Rigal Anne Hitzel Julien Delrieu Pierre-Jean Ousset Françoise Lala Nathalie Sastre-Hengan Olivier Morel 16 Olivier Rouaud 17 Denis Mariano-Goulart 18 Dimitri Papathanassiou 19 Florence Le Jeune 20 Andrew Stephens 2 Eric Guedj 2
Abstract : Introduction Although some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting. Methods This multicenter study was performed at French tertiary memory clinics in patients presenting with most complex clinical situations (i.e., early-onset, atypical clinical profiles, suspected mixed etiological conditions, unexpected rate of progression), for whom cerebrospinal fluid analysis was indicated but either not feasible or considered as noncontributory (ClinicalTrials.gov: NCT02681172). Results Two hundred five patients were enrolled with evaluable florbetaben PET scans; 64.4% of scans were amyloid positive. PET results led to changed diagnosis and improved confidence in 66.8% and 81.5% of patients, respectively, and altered management in 80.0% of cases. Discussion High-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases.
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Submitted on : Tuesday, June 22, 2021 - 10:57:24 AM
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Mathieu Ceccaldi, Thérèse Jonveaux, Antoine Verger, Pierre Krolak-Salmon, Claire Houzard, et al.. Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2018, 14 (3), pp.293 - 305. ⟨10.1016/j.jalz.2017.09.009⟩. ⟨hal-03266901⟩

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