Skip to Main content Skip to Navigation
Journal articles

Prognostic Impact of 18-F-Florbetaben Amyloid PET Imaging in Patients with Isolated Increases in Cerebrospinal Fluid Phospho-Tau Biomarkers: A Longitudinal Study

Abstract : This longitudinal study evaluates the prognostic impact of amyloid PET in patients suspected of Alzheimer’s disease and presenting with isolated cerebrospinal fluid (CSF) increases in P-Tau proteins (NCT02556502). The rate of conversion, based on the DSM-5 criteria and all collected data (average follow-up of 39.2±13.2 months), was determined by a panel of experts blinded to the PET results and was 75%(6/8) for positive and 35%(6/17) for negative baseline amyloid PET. In this population with isolated CSF increases in P-Tau, a positive baseline amyloid PET was associated with greater than twice the proportion of dementia conversions within the following three years.
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03266987
Contributor : Juliette Birker <>
Submitted on : Tuesday, June 22, 2021 - 11:29:26 AM
Last modification on : Tuesday, September 14, 2021 - 4:06:05 PM

Identifiers

Citation

Amory Jardel, Lucie Hopes, Catherine Malaplate, Véronique Roch, Chloé Manca, et al.. Prognostic Impact of 18-F-Florbetaben Amyloid PET Imaging in Patients with Isolated Increases in Cerebrospinal Fluid Phospho-Tau Biomarkers: A Longitudinal Study. Journal of Alzheimer's Disease, IOS Press, 2021, 80 (4), pp.1389-1394. ⟨10.3233/JAD-201435⟩. ⟨hal-03266987⟩

Share

Metrics

Record views

25