Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Cardiovascular Diabetology Année : 2021

Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial

Franco Cosmi
  • Fonction : Auteur
Stephane R B Heymans
  • Fonction : Auteur
  • PersonId : 1103658

Résumé

Abstract Background Patients with diabetes mellitus (DM) are at increased risk of developing heart failure (HF). The “Heart OMics in AGEing” (HOMAGE) trial suggested that spironolactone had beneficial effect on fibrosis and cardiac remodelling in an at risk population, potentially slowing the progression towards HF. We compared the proteomic profile of patients with and without diabetes among patients at risk for HF in the HOMAGE trial. Methods Protein biomarkers (n = 276) from the Olink®Proseek-Multiplex cardiovascular and inflammation panels were measured in plasma collected at baseline and 9 months (or last visit) from HOMAGE trial participants including 217 patients with, and 310 without, diabetes. Results Twenty-one biomarkers were increased and five decreased in patients with diabetes compared to non-diabetics at baseline. The markers clustered mainly within inflammatory and proteolytic pathways, with granulin as the key-hub, as revealed by knowledge-induced network and subsequent gene enrichment analysis. Treatment with spironolactone in diabetic patients did not lead to large changes in biomarkers. The effects of spironolactone on NTproBNP, fibrosis biomarkers and echocardiographic measures of diastolic function were similar in patients with and without diabetes (all interaction analyses p > 0.05). Conclusions Amongst patients at risk for HF, those with diabetes have higher plasma concentrations of proteins involved in inflammation and proteolysis. Diabetes does not influence the effects of spironolactone on the proteomic profile, and spironolactone produced anti-fibrotic, anti-remodelling, blood pressure and natriuretic peptide lowering effects regardless of diabetes status. Trial registration NCT02556450.
Fichier principal
Vignette du fichier
s12933-021-01357-9.pdf (1.72 Mo) Télécharger le fichier
12933_2021_1357_MOESM1_ESM.docx (41.65 Ko) Télécharger le fichier
12933_2021_1357_MOESM1_ESM.pdf (534.7 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03320862 , version 1 (16-08-2021)

Licence

Paternité

Identifiants

Citer

Job a J Verdonschot, João Pedro Ferreira, Pierpaolo Pellicori, Hans-Peter Brunner-La Rocca, Andrew L Clark, et al.. Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial. Cardiovascular Diabetology, 2021, 20 (1), pp.163. ⟨10.1186/s12933-021-01357-9⟩. ⟨hal-03320862⟩
53 Consultations
156 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More