Skip to Main content Skip to Navigation
New interface
Journal articles

Combined omics approaches reveal distinct responses between light and heavy rare earth elements in Saccharomyces cerevisiae

Abstract : The rapid development of green energy sources and new medical technologies contributes to the increased exploitation of rare earth elements (REEs). They can be subdivided into light (LREEs) and heavy (HREEs) REEs. Mining, industrial processing, and end-use practices of REEs has led to elevated environmental concentrations and raises concerns about their toxicity to organisms and their impact on ecosystems. REE toxicity has been reported, but its precise underlying molecular effects have not been well described. Here, transcriptomic and proteomic approaches were combined to decipher the molecular responses of the model organism Saccharomyces cerevisiae to La (LREE) and Yb (HREE). Differences were observed between the early and late responses to La and Yb. Several crucial pathways were modulated in response to both REEs, such as oxidative-reduction processes, DNA replication, and carbohydrate metabolism. REE-specific responses involving the cell wall and pheromone signalling pathways were identified, and these responses have not been reported for other metals. REE exposure also modified the expression and abundance of several ion transport systems, with strong discrepancies between La and Yb. These findings are valuable for prioritizing key genes and proteins involved in La and Yb detoxification mechanisms that deserve further characterization to better understand REE environmental and human health toxicity.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03514152
Contributor : Damien Blaudez Connect in order to contact the contributor
Submitted on : Thursday, January 6, 2022 - 10:52:39 AM
Last modification on : Wednesday, September 28, 2022 - 4:53:40 AM
Long-term archiving on: : Thursday, April 7, 2022 - 6:48:07 PM

File

Grosjean_JHM_version HAL.pdf
Files produced by the author(s)

Identifiers

Citation

Nicolas Grosjean, Marie Le Jean, Jean Armengaud, Adam Schikora, Michel Chalot, et al.. Combined omics approaches reveal distinct responses between light and heavy rare earth elements in Saccharomyces cerevisiae. Journal of Hazardous Materials, 2022, 425, pp.127830. ⟨10.1016/j.jhazmat.2021.127830⟩. ⟨hal-03514152⟩

Share

Metrics

Record views

114

Files downloads

27