HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Cardiac structure and function and quality of life associations in HFpEF: An analysis from TOPCAT-Americas

Abstract : Background: Patients with heart failure with preserved ejection fraction (HFpEF) have poor health-related quality of life (HR-QoL). However, the relationship between HR-QoL measures and the alterations of cardiac structure and function that are present in patients with HFpEF remains unknown. Aims: To study the associations between HR-QoL and echocardiographic parameters in HFpEF. Methods: Regression modelling in patients from TOPCAT-Americas who had both HR-QoL questionnaires and a baseline echocardiogram. Results: A total of 631 patients (36% of the TOPCAT-Americas population) had both echocardiographic and HR-QoL at baseline. KCCQ-23 Overall Summary Score (OSS; 0-100 points) was negatively (higher echocardiographic values-poorer/lower HR-QoL scores) associated with left ventricular end-diastolic diameter (LVEDD: β = -3.56 [-7.00 to -0.13] points-per-1 cm, P = 0.042), interventricular septum thickness (β = -1.31 [-2.19 to -0.42] points-per-1 mm, P = 0.004), posterior wall thickness (β = -1.57 [-2.52 to -0.63] points-per-1 mm, P = 0.001 and left atrial width (β = -3.27 [-6.39 to -0.15], P = 0.040) points-per-1 cm, and positively (higher echocardiographic values-better/higher HR-QoL scores) associated with left ventricular end-diastolic volume index (LVEDVi: β = 0.23 [0.09 to 0.37] points-per-1 ml/m2, P = 0.002) and left ventricular end-systolic volume index (LVESVi: β = 0.41 [0.18 to 0.63] points-per-1 ml/m2, P < 0.001). Body mass index (BMI: β = -0.74 [-1.02 to -0.47] points-per-1Kg/m2, P < 0.001), diabetes (β = -6.01 [-10.05 to -1.97], P = 0.004), and asthma (β = -6.78 [-13.52 to -0.04], P = 0.049) were negatively associated with OSS. A similar pattern of associations was observed for KCCQ-23 Clinical Summary Score, EQ5D-VAS and NYHA class. Conclusion: In patients with HFpEF, HR-QoL measures were associated with cardiac structure and function alterations. Extra-cardiac factors were also associated with HR-QoL, which may influence HR-QoL results when testing cardiovascular drugs.
Complete list of metadata

Contributor : Erwan Bozec Connect in order to contact the contributor
Submitted on : Wednesday, February 2, 2022 - 12:19:59 PM
Last modification on : Friday, April 22, 2022 - 11:42:06 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2022-07-29

Please log in to resquest access to the document




João Ferreira, Amil Shah, Brian Claggett, Bertram Pitt, Eldrin Lewis, et al.. Cardiac structure and function and quality of life associations in HFpEF: An analysis from TOPCAT-Americas. International Journal of Cardiology, Elsevier, 2022, ⟨10.1016/j.ijcard.2022.01.053⟩. ⟨hal-03552530⟩



Record views