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Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard

Abstract : Due to the lack of efficacy of synthetic vascular substitutes in the replacement of small-caliber arteries, vascular tissue engineering (VTE) has emerged as a promising solution to produce viable small-caliber tissue-engineered vascular grafts (TEVG). Previous studies have shown the importance of a cellular intimal layer at the luminal surface of TEVG to prevent thrombotic events. However, the cellularization of a TEVG seems to be a critical approach to consider in the development of a TEVG. To date, no standard cellularization method or cell type has been established to create the ideal TEVG by promoting its long-term patency and function. In this review, advances in VTE are described and discussed with a particular focus on the construction approaches of cellularized small-caliber TEVGs, the cell types used, as well as their preclinical and clinical applications.
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https://hal.univ-lorraine.fr/hal-03557772
Contributor : Marie-Helene Piet Connect in order to contact the contributor
Submitted on : Thursday, February 10, 2022 - 9:56:15 AM
Last modification on : Friday, April 1, 2022 - 3:53:51 AM

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Adrien Fayon, Patrick Menu, Reine El Omar. Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard. NPJ Regenerative medicine, Springer Nature, 2021, 6 (1), pp.46. ⟨10.1038/s41536-021-00155-x⟩. ⟨hal-03557772⟩

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