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Article Dans Une Revue European Journal of Organic Chemistry Année : 2022

Synthetic Modifications of the Linkage Region of Proteoglycans and Impact on CSGalNAcT‐1

Résumé

Multi-step synthesis of a library of variously modified disaccharides and trisaccharides of the linkage region of proteoglycans (PGs) having a d-galactose modified at position C-2, C-4 or C-6 position by replacing the hydroxyl group by methoxy or deoxy moieties is described. Preliminary results of the impact of these modifications upon CSGalNAcT-1 are also reported.

Domaines

Chimie organique
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Dates et versions

hal-03564227 , version 1 (10-02-2022)

Identifiants

Citer

Benjamin Ayela, Floriane Heis, Thomas Poisson, Xavier Pannecoucke, Sylvie Fournel‐gigleux, et al.. Synthetic Modifications of the Linkage Region of Proteoglycans and Impact on CSGalNAcT‐1. European Journal of Organic Chemistry, 2022, 2022 (2), pp.e202101422. ⟨10.1002/ejoc.202101422⟩. ⟨hal-03564227⟩
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