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Journal Articles Circulation Research Year : 2016

Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence

Abstract

Systemic hypertension is a risk factor for many diseases affecting the heart, brain, and kidneys. It has long been thought that hypertension leads to a thickening and stiffening of central arteries (i.e., stiffness is a consequence) while more recent evidence suggests that stiffening precedes hypertension (i.e., stiffness is a cause). We submit, however, that consideration of the wall biomechanics and hemodynamics reveals an insidious positive feedback loop that may render it irrelevant whether hypertension causes or is caused by central arterial stiffening. A progressive worsening can ensue in either case, thus any onset of stiffening merits early intervention.

Dates and versions

hal-03571209 , version 1 (13-02-2022)

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Jay Humphrey, David Harrison, C. Alberto Figueroa, Patrick Lacolley, Stéphane Laurent. Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence. Circulation Research, 2016, 118 (3), pp.379-381. ⟨10.1161/CIRCRESAHA.115.307722⟩. ⟨hal-03571209⟩
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