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Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence

Abstract : Systemic hypertension is a risk factor for many diseases affecting the heart, brain, and kidneys. It has long been thought that hypertension leads to a thickening and stiffening of central arteries (i.e., stiffness is a consequence) while more recent evidence suggests that stiffening precedes hypertension (i.e., stiffness is a cause). We submit, however, that consideration of the wall biomechanics and hemodynamics reveals an insidious positive feedback loop that may render it irrelevant whether hypertension causes or is caused by central arterial stiffening. A progressive worsening can ensue in either case, thus any onset of stiffening merits early intervention.
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https://hal.univ-lorraine.fr/hal-03571209
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Submitted on : Sunday, February 13, 2022 - 10:22:12 PM
Last modification on : Thursday, April 7, 2022 - 1:58:21 PM

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Jay Humphrey, David Harrison, C. Alberto Figueroa, Patrick Lacolley, Stéphane Laurent. Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence. Circulation Research, American Heart Association, 2016, 118 (3), pp.379-381. ⟨10.1161/CIRCRESAHA.115.307722⟩. ⟨hal-03571209⟩

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