HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Book section

Immune Monitoring

Abstract : Abstract CAR-T cell expansion and persistence are critical parameters for therapeutic efficacy and toxicity (Locke et al. 2020). However, CAR-T cells are patient-specific ‘living drugs’ with an unpredictable ability to expand in vivo. Thus, close postinfusion monitoring should be a major prerequisite to better manage this therapy. Critical parameters include CAR-T cell expansion kinetics and phenotype immune reconstitution and serum biomarkers (Fig. 35.1; Kalos et al. 2011; Hu and Huang 2020). Additionally, prospective collection and storage of patient specimens should be planned for future hypothesis-driven studies at specialized research centres. To date, despite the rapid expansion of CAR-T cell therapy, no standard recommendations exist for CAR monitoring, and harmonization of efforts across multiple centres is urgently needed.
Document type :
Book section
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03629073
Contributor : Céline Huselstein Connect in order to contact the contributor
Submitted on : Monday, April 4, 2022 - 9:34:38 AM
Last modification on : Tuesday, April 5, 2022 - 4:49:59 PM

Links full text

Identifiers

Collections

Citation

Susanna Carolina Berger, Boris Fehse, Marie-Thérèse Rubio. Immune Monitoring. The EBMT/EHA CAR-T Cell Handbook, Springer International Publishing, pp.177-182, 2022, 978-3-030-94352-3. ⟨10.1007/978-3-030-94353-0_35⟩. ⟨hal-03629073⟩

Share

Metrics

Record views

7