HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

Abstract : Background The gut microbiome is essential for physiological host responses and development of immune functions. The impact of gut microbiota on blood pressure and systemic vascular function, processes that are determined by immune cell function, is unknown. Methods and Results Unchallenged germ‐free mice ( GF ) had a dampened systemic T helper cell type 1 skewing compared to conventionally raised ( CONV ‐R) mice. Colonization of GF mice with regular gut microbiota induced lymphoid mRNA transcription of T‐box expression in T cells and resulted in mild endothelial dysfunction. Compared to CONV ‐R mice, angiotensin II (Ang II ; 1 mg/kg per day for 7 days) infused GF mice showed reduced reactive oxygen species formation in the vasculature, attenuated vascular mRNA expression of monocyte chemoattractant protein 1 ( MCP ‐1), inducible nitric oxide synthase (iNOS) and NADPH oxidase subunit Nox2, as well as a reduced upregulation of retinoic‐acid receptor‐related orphan receptor gamma t (Rorγt), the signature transcription factor for interleukin (IL)‐17 synthesis. This resulted in an attenuated vascular leukocyte adhesion, less infiltration of Ly6G + neutrophils and Ly6C + monocytes into the aortic vessel wall, protection from kidney inflammation, as well as endothelial dysfunction and attenuation of blood pressure increase in response to Ang II . Importantly, cardiac inflammation, fibrosis and systolic dysfunction were attenuated in GF mice, indicating systemic protection from cardiovascular inflammatory stress induced by AngII. Conclusion Gut microbiota facilitate Ang II ‐induced vascular dysfunction and hypertension, at least in part, by supporting an MCP ‐1/ IL ‐17 driven vascular immune cell infiltration and inflammation.
Complete list of metadata

https://hal.univ-lorraine.fr/hal-03641710
Contributor : Jeremy Lagrange Connect in order to contact the contributor
Submitted on : Thursday, April 14, 2022 - 2:29:14 PM
Last modification on : Friday, April 15, 2022 - 3:04:38 AM

Links full text

Identifiers

Collections

Citation

Susanne Karbach, Tanja Schönfelder, Ines Brandão, Eivor Wilms, Nives Hörmann, et al.. Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction. Journal of the American Heart Association, Wiley-Blackwell, 2016, 5 (9), ⟨10.1161/JAHA.116.003698⟩. ⟨hal-03641710⟩

Share

Metrics

Record views

6