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Préoccupations et besoins d’aide psychologiques chez les femmes à risque génétique de cancer du sein ou de l’ovaire : une étude prospective observationnelle en Allemagne, Espagne et France

Abstract : Objectives and background : The introduction of gene panel testing has increased the complexity of communication in cancer genetic consultations. Attention to the impact of this communication on the patients’ concerns and needs for psychological help is even more necessary. This study aims to quantify the type and extent of these concerns and needs before and after communication of the genetic test results in women attending cancer genetic counselling for breast and ovarian cancer susceptibility testing in Germany, Spain and France. Participants and measurements : Of the 752 individuals consecutively invited to participate in this study, 646 (86%)—of whom 510 (68%) had breast cancer—completed a questionnaire PAHC ( Psychosocial Aspects of Hereditary Cancer ) on specific concerns about the cancer genetic process and their need for psychological support, administered after the initial consultation (T1) and, for 460 (61%) of them, two months after the communication of the test result (T2). Results : Seventy-nine (17.2%), 19 (4.1%), 259 (56.3%), 44 (9.6%), and 59 (12.8%) women had the following results respectively: a pathogenic variant on BRCA1/2 or another high or moderate risk gene, a non-informative negative result, a true negative result, or the presence of a variant of uncertain clinical significance (VUS). The type of concerns and the need for counselling were found to vary between countries. However, overall, the most frequent concerns (> 70%) were related to the loss of a family member to cancer, and the least frequent (< 5%) were related to support for relatives. Most of these concerns persisted two months later following the genetic test result. In contrast, the need for psychological help decreased overall statistically, except, depending on the country, for family/social concerns, emotional difficulties or practical aspects. Conclusions : In our study of women from three European countries attending cancer genetic counselling for breast or ovarian cancer susceptibility testing, most concerns related to the genetic situation persist two months after the communication of the test result and the need for psychological help is mainly in the field of relationships and emotions.
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https://hal.univ-lorraine.fr/hal-03656305
Contributor : Jean-Luc Kop Connect in order to contact the contributor
Submitted on : Monday, May 2, 2022 - 9:28:42 AM
Last modification on : Saturday, May 14, 2022 - 3:12:23 AM

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A. Brédart, Jean-Luc Kop, A. de Pauw, A. Cano, J. Dick, et al.. Préoccupations et besoins d’aide psychologiques chez les femmes à risque génétique de cancer du sein ou de l’ovaire : une étude prospective observationnelle en Allemagne, Espagne et France. Psycho-Oncologie, Springer, 2021, 15 (4), pp.121-130. ⟨10.3166/pson-2021-0169⟩. ⟨hal-03656305⟩

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