Noncoding RNAs as additional mediators of epigenetic regulation in nonalcoholic fatty liver disease - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue World Journal of Gastroenterology Année : 2022

Noncoding RNAs as additional mediators of epigenetic regulation in nonalcoholic fatty liver disease

Mohamed Zaiou

Résumé

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common cause of chronic liver disorder worldwide. It represents a spectrum that includes a continuum of different clinical entities ranging from simple steatosis to nonalcoholic steatohepatitis, which can evolve to cirrhosis and in some cases to hepatocellular carcinoma, ultimately leading to liver failure. The pathogenesis of NAFLD and the mechanisms underlying its progression to more pathological stages are not completely understood. Besides genetic factors, evidence indicates that epigenetic mechanisms occurring in response to environmental stimuli also contribute to the disease risk. Noncoding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, are one of the epigenetic factors that play key regulatory roles in the development of NAFLD. As the field of ncRNAs is rapidly evolving, the present review aims to explore the current state of knowledge on the roles of these RNA species in the pathogenesis of NAFLD, highlight relevant mechanisms by which some ncRNAs can modulate regulatory networks implicated in NAFLD, and discuss key challenges and future directions facing current research in the hopes of developing ncRNAs as next-generation non-invasive diagnostics and therapies in NAFLD and subsequent progression to hepatocellular carcinoma.

Dates et versions

hal-03936431 , version 1 (12-01-2023)

Identifiants

Citer

Mohamed Zaiou. Noncoding RNAs as additional mediators of epigenetic regulation in nonalcoholic fatty liver disease. World Journal of Gastroenterology, 2022, 28 (35), pp.5111-5128. ⟨10.3748/wjg.v28.i35.5111⟩. ⟨hal-03936431⟩
16 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More