Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study - Université de Lorraine Access content directly
Journal Articles Circulation. Heart failure Year : 2023

Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study

1 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
2 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
3 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
4 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
5 NHLBI - National Heart, Lung, and Blood Institute [Bethesda]
6 Boston University's Framingham Heart Study
7 BCM - Baylor College of Medicine
8 LSHTM - London School of Hygiene and Tropical Medicine
9 IBENS - Institut de biologie de l'ENS Paris
10 PSL - Université Paris Sciences et Lettres
11 TATAA Biocenter AB
12 UMMC - University of Mississippi Medical Center
13 Hull York Medical School
14 Castle Hill Hospital
15 University of Glasgow
16 NHLI - National Heart and Lung Institute [London]
17 CIMA - Center for Applied Medical Research [Plamplona]
18 Institute of Health Carlos III
19 UNAV - Universidad de Navarra [Pamplona]
20 IdiSNA - Navarra Institute for Health Research / Instituto de Investigación Sanitaria de Navarra
21 MUMC - Maastricht University Medical Centre
22 CARIM - Cardiovascular Research Institute Maastricht
23 Maastricht University Hospital
24 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
25 Cortona Hospital
26 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
27 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
28 Imperial College London
29 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
30 The Netherlands Heart Institute
Christie Ballantyne
Jens Björkman
Javed Butler
Andrew Clark
Christian Delles
Pierpaolo Pellicori
Naveed Sattar

Abstract

Background: We sought to identify protein biomarkers of new-onset heart failure (HF) in 3 independent cohorts (HOMAGE cohort [Heart Omics and Ageing], ARIC study [Atherosclerosis Risk in Communities], and FHS [Framingham Heart Study]) and assess if and to what extent they improve HF risk prediction compared to clinical risk factors alone. Methods: A nested case-control design was used with cases (incident HF) and controls (without HF) matched on age and sex within each cohort. Plasma concentrations of 276 proteins were measured at baseline in ARIC (250 cases/250 controls), FHS (191/191), and HOMAGE cohort (562/871). Results: In single protein analysis, after adjusting for matching variables and clinical risk factors (and correcting for multiple testing), 62 proteins were associated with incident HF in ARIC, 16 in FHS, and 116 in HOMAGE cohort. Proteins associated with incident HF in all cohorts were BNP (brain natriuretic peptide), NT-proBNP (N-terminal pro-B-type natriuretic peptide), eukaryotic translation initiation factor 4E-BP1 (4E-binding protein 1), hepatocyte growth factor (HGF), Gal-9 (galectin-9), TGF-alpha (transforming growth factor alpha), THBS2 (thrombospondin-2), and U-PAR (urokinase plasminogen activator surface receptor). The increment in C -index for incident HF based on a multiprotein biomarker approach, in addition to clinical risk factors and NT-proBNP, was 11.1% (7.5%–14.7%) in ARIC, 5.9% (2.6%–9.2%) in FHS, and 7.5% (5.4%–9.5%) in HOMAGE cohort, all P <0.001), each of which was a larger increase than that for NT-proBNP on top of clinical risk factors. Complex network analysis revealed a number of overrepresented pathways related to inflammation (eg, tumor necrosis factor and interleukin) and remodeling (eg, extracellular matrix and apoptosis). Conclusions: A multiprotein biomarker approach improves prediction of incident HF when added to natriuretic peptides and clinical risk factors.
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hal-04099796 , version 1 (17-05-2023)

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Nicolas Girerd, Daniel Levy, Kevin Duarte, Joao Pedro Ferreira, Christie Ballantyne, et al.. Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circulation. Heart failure, 2023, 16 (5), pp.e009694. ⟨10.1161/CIRCHEARTFAILURE.122.009694⟩. ⟨hal-04099796⟩
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